1,3-Bis(p-tolylsulfonyl)hexahydropyrimidine-5-ol

Base Information

Chemical Name:1,3-Bis(p-tolylsulfonyl)hexahydropyrimidine-5-ol
CAS No.:261507-85-1
Molecular Formula:C₁₈H₂₂N₂O₅S₂
Molecular Weight:410.515
Hs Code.:
DSSTox Substance ID:DTXSID601198571
Nikkaji Number:J1.277.778G

Synonyms:DTXSID601198571;1,3-Bis(p-tolylsulfonyl)hexahydropyrimidine-5-ol;Hexahydro-1,3-bis[(4-methylphenyl)sulfonyl]-5-pyrimidinol;261507-85-1

Suppliers and Price of 1,3-Bis(p-tolylsulfonyl)hexahydropyrimidine-5-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1,3-Bis(p-tolylsulfonyl)hexahydropyrimidine-5-ol

Chemical Property:

XLogP3:1.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:4
Exact Mass:410.09701415
Heavy Atom Count:27
Complexity:637

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=CC=C(C=C1)S(=O)(=O)N2CC(CN(C2)S(=O)(=O)C3=CC=C(C=C3)C)O

Technology Process of 1,3-Bis(p-tolylsulfonyl)hexahydropyrimidine-5-ol

There total 1 articles about 1,3-Bis(p-tolylsulfonyl)hexahydropyrimidine-5-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 98-59-9
p-toluenesulfonyl chloride

: 64579-88-0
5-hydroxy-1,3-diazacyclohexane

: 261507-85-1
1,3-di(p-toluenesulfonyl)-5-hydroxy-1,3-diazacyclohexane

Guidance literature:: With potassium carbonate; In tetrahydrofuran; water; at 20 ℃; for 3h;
DOI:10.1021/jo991524o

Reference yield: 76.0%

: 261507-85-1
1,3-di(p-toluenesulfonyl)-5-hydroxy-1,3-diazacyclohexane

: 261507-95-3
1,3-di(p-toluenesulfonyl)-1,3-diazacyclohexan-5-one

Guidance literature:: With chromium(VI) oxide; sulfuric acid; In acetone; at 20 ℃; for 2.5h;
DOI:10.1021/jo991524o

Reference yield:

: 261507-85-1
1,3-di(p-toluenesulfonyl)-5-hydroxy-1,3-diazacyclohexane

: 1,4-dioxa-7,9-ditosyl-7,9-diazaspiro[4.5]decane

Guidance literature:: Multi-step reaction with 2 steps

1: 76 percent / CrO₃; aq. H₂SO₄ / acetone / 2.5 h / 20 °C

2: 90 percent / TsOH*H₂O / benzene / 20 h / Thermolysis

With chromium(VI) oxide; sulfuric acid; toluene-4-sulfonic acid; In acetone; benzene; 1: Oxidation / 2: Addition;
DOI:10.1021/jo991524o