(1R,3S,4R,4aS,17aR)-4-Benzyloxy-1-butoxymethyl-3-methoxy-11-(toluene-4-sulfonyl)-dodecahydro-2,5,8,14,17-pentaoxa-11-aza-benzocyclopentadecene

Base Information

Chemical Name:(1R,3S,4R,4aS,17aR)-4-Benzyloxy-1-butoxymethyl-3-methoxy-11-(toluene-4-sulfonyl)-dodecahydro-2,5,8,14,17-pentaoxa-11-aza-benzocyclopentadecene
CAS No.:332057-88-2
Molecular Formula:C₃₃H₄₉NO₁₀S
Molecular Weight:651.819
Hs Code.:

(1R,3S,4R,4aS,17aR)-4-Benzyloxy-1-butoxymethyl-3-methoxy-11-(toluene-4-sulfonyl)-dodecahydro-2,5,8,14,17-pentaoxa-11-aza-benzocyclopentadecene

Synonyms:(1R,3S,4R,4aS,17aR)-4-Benzyloxy-1-butoxymethyl-3-methoxy-11-(toluene-4-sulfonyl)-dodecahydro-2,5,8,14,17-pentaoxa-11-aza-benzocyclopentadecene

Suppliers and Price of (1R,3S,4R,4aS,17aR)-4-Benzyloxy-1-butoxymethyl-3-methoxy-11-(toluene-4-sulfonyl)-dodecahydro-2,5,8,14,17-pentaoxa-11-aza-benzocyclopentadecene

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (1R,3S,4R,4aS,17aR)-4-Benzyloxy-1-butoxymethyl-3-methoxy-11-(toluene-4-sulfonyl)-dodecahydro-2,5,8,14,17-pentaoxa-11-aza-benzocyclopentadecene

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (1R,3S,4R,4aS,17aR)-4-Benzyloxy-1-butoxymethyl-3-methoxy-11-(toluene-4-sulfonyl)-dodecahydro-2,5,8,14,17-pentaoxa-11-aza-benzocyclopentadecene

There total 9 articles about (1R,3S,4R,4aS,17aR)-4-Benzyloxy-1-butoxymethyl-3-methoxy-11-(toluene-4-sulfonyl)-dodecahydro-2,5,8,14,17-pentaoxa-11-aza-benzocyclopentadecene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 109-65-9
1-bromo-butane

: 332057-71-3
[(1R,3S,4R,4aS,17aR)-4-Benzyloxy-3-methoxy-11-(toluene-4-sulfonyl)-dodecahydro-2,5,8,14,17-pentaoxa-11-aza-benzocyclopentadecen-1-yl]-methanol

: 332057-88-2
(1R,3S,4R,4aS,17aR)-4-Benzyloxy-1-butoxymethyl-3-methoxy-11-(toluene-4-sulfonyl)-dodecahydro-2,5,8,14,17-pentaoxa-11-aza-benzocyclopentadecene

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 40 ℃; for 10h;
DOI:10.3987/COM-00-9098

Reference yield:

: 53958-32-0,15038-69-4,81348-16-5,86427-99-8,100662-84-8
methyl α-D-glucopyranoside 2-benzyl ether

: 332057-88-2
(1R,3S,4R,4aS,17aR)-4-Benzyloxy-1-butoxymethyl-3-methoxy-11-(toluene-4-sulfonyl)-dodecahydro-2,5,8,14,17-pentaoxa-11-aza-benzocyclopentadecene

Guidance literature:: Multi-step reaction with 6 steps

1: pyridine / 8 h / 40 °C

2: 2 h / 20 °C

3: 83 percent / aq. NaOH; NBu₄*HSO₄ / 12 h / 20 °C

4: 72 percent / K₂CO₃ / dimethylformamide / 36 h / 120 °C

5: 97 percent / TMSCl; NaI / acetonitrile / 0.08 h / 20 °C

6: 90 percent / NaH / dimethylformamide / 10 h / 40 °C

With pyridine; sodium hydroxide; chloro-trimethyl-silane; tetra(n-butyl)ammonium hydrogensulfate; sodium hydride; potassium carbonate; sodium iodide; In N,N-dimethyl-formamide; acetonitrile;
DOI:10.3987/COM-00-9098

Reference yield:

: 100-39-0
benzyl bromide

: 332057-88-2
(1R,3S,4R,4aS,17aR)-4-Benzyloxy-1-butoxymethyl-3-methoxy-11-(toluene-4-sulfonyl)-dodecahydro-2,5,8,14,17-pentaoxa-11-aza-benzocyclopentadecene

Guidance literature:: Multi-step reaction with 8 steps

1.1: Bu₂SnO / methanol / 1 h / Heating

1.2: 83 percent / 11 h / 110 °C

2.1: 100 percent / aq. HCl / tetrahydrofuran; methanol / 4 h / Heating

3.1: pyridine / 8 h / 40 °C

4.1: 2 h / 20 °C

5.1: 83 percent / aq. NaOH; NBu₄*HSO₄ / 12 h / 20 °C

6.1: 72 percent / K₂CO₃ / dimethylformamide / 36 h / 120 °C

7.1: 97 percent / TMSCl; NaI / acetonitrile / 0.08 h / 20 °C

8.1: 90 percent / NaH / dimethylformamide / 10 h / 40 °C

With pyridine; hydrogenchloride; sodium hydroxide; chloro-trimethyl-silane; tetra(n-butyl)ammonium hydrogensulfate; sodium hydride; di(n-butyl)tin oxide; potassium carbonate; sodium iodide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.3987/COM-00-9098