methyl 1,4-dibenzoyl-2-(4-fluorophenyl)-5-(4-nitrophenyl)-2,5-dihydro-1H-pyrrole-2-carboxylate

Base Information

Chemical Name:methyl 1,4-dibenzoyl-2-(4-fluorophenyl)-5-(4-nitrophenyl)-2,5-dihydro-1H-pyrrole-2-carboxylate
CAS No.:1325732-14-6
Molecular Formula:C₃₂H₂₃FN₂O₆
Molecular Weight:550.543
Hs Code.:

Synonyms:methyl 1,4-dibenzoyl-2-(4-fluorophenyl)-5-(4-nitrophenyl)-2,5-dihydro-1H-pyrrole-2-carboxylate

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Chemical Property of methyl 1,4-dibenzoyl-2-(4-fluorophenyl)-5-(4-nitrophenyl)-2,5-dihydro-1H-pyrrole-2-carboxylate

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Technology Process of methyl 1,4-dibenzoyl-2-(4-fluorophenyl)-5-(4-nitrophenyl)-2,5-dihydro-1H-pyrrole-2-carboxylate

There total 5 articles about methyl 1,4-dibenzoyl-2-(4-fluorophenyl)-5-(4-nitrophenyl)-2,5-dihydro-1H-pyrrole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1325732-16-8
methyl 4-benzoyl-2-(4-fluorophenyl)-5-(4-nitrophenyl)-2,5-dihydro-1H-pyrrole-2-carboxylate

: 98-88-4
benzoyl chloride

: 1325732-14-6
methyl 1,4-dibenzoyl-2-(4-fluorophenyl)-5-(4-nitrophenyl)-2,5-dihydro-1H-pyrrole-2-carboxylate

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃;
DOI:10.1021/ol201898x

Reference yield:

: 89530-34-7
1-phenyl-3-trimethylsilylprop-2-yn-1-ol

: 1325732-14-6
methyl 1,4-dibenzoyl-2-(4-fluorophenyl)-5-(4-nitrophenyl)-2,5-dihydro-1H-pyrrole-2-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / methanol / 2 h / 20 °C

2: manganese(IV) oxide / dichloromethane / 0 - 20 °C

3: (R)-3,3'-bis(9-anthracenyl)-1,1'-binaphthyl-2,2'-diyl hydrogenphosphate / toluene / 144 h / 50 °C / Molecular sieve

4: triethylamine / dichloromethane / 0 - 20 °C

With (R)-3,3'-bis(9-anthracenyl)-1,1'-binaphthyl-2,2'-diyl hydrogenphosphate; manganese(IV) oxide; potassium carbonate; triethylamine; In methanol; dichloromethane; toluene;
DOI:10.1021/ol201898x

Reference yield:

: 100-52-7
benzaldehyde

: 1325732-14-6
methyl 1,4-dibenzoyl-2-(4-fluorophenyl)-5-(4-nitrophenyl)-2,5-dihydro-1H-pyrrole-2-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere

1.2: 1 h / -78 - 20 °C / Inert atmosphere

2.1: potassium carbonate / methanol / 2 h / 20 °C

3.1: manganese(IV) oxide / dichloromethane / 0 - 20 °C

4.1: (R)-3,3'-bis(9-anthracenyl)-1,1'-binaphthyl-2,2'-diyl hydrogenphosphate / toluene / 144 h / 50 °C / Molecular sieve

5.1: triethylamine / dichloromethane / 0 - 20 °C

With (R)-3,3'-bis(9-anthracenyl)-1,1'-binaphthyl-2,2'-diyl hydrogenphosphate; manganese(IV) oxide; n-butyllithium; potassium carbonate; triethylamine; In tetrahydrofuran; methanol; hexane; dichloromethane; toluene;
DOI:10.1021/ol201898x