(S)-2-(benzyloxycarbonylamino)-4-cyanobutanoate

Base Information

• Chemical Name: (S)-2-(benzyloxycarbonylamino)-4-cyanobutanoate
• CAS No.: 864296-75-3
• Molecular Formula: C₁₅H₁₈N₂O₄
• Molecular Weight: 290.319
• Mol file: 864296-75-3.mol

Synonyms:(S)-2-(benzyloxycarbonylamino)-4-cyanobutanoate

Chemical Property of (S)-2-(benzyloxycarbonylamino)-4-cyanobutanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-(benzyloxycarbonylamino)-4-cyanobutanoate

There total 4 articles about (S)-2-(benzyloxycarbonylamino)-4-cyanobutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

N2-benzyloxycarbonyl-l-glutamine ethyl ester (4668-41-1) → (S)-2-(benzyloxycarbonylamino)-4-cyanobutanoate (864296-75-3)

Guidance literature:

With pyridine; trifluoroacetic anhydride; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1002/ejoc.201100404

Reference yield: 98.0%

dicyclohexylammonium (2S)-2-(benzyloxycarbonyl-amino)-4-cyano-butanoate + ethanol (64-17-5) → (S)-2-(benzyloxycarbonylamino)-4-cyanobutanoate (864296-75-3)

Guidance literature:

dicyclohexylammonium (2S)-2-(benzyloxycarbonyl-amino)-4-cyano-butanoate; With water; citric acid;

ethanol; With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In DMF (N,N-dimethyl-formamide); for 16h; Heating / reflux;

Reference yield:

ethanol (64-17-5) + (S)-2-((phenylmethoxycarbonyl)amino)-4-cyanobutanoic acid (15231-21-7) → (S)-2-(benzyloxycarbonylamino)-4-cyanobutanoate (864296-75-3)

Guidance literature:

(S)-2-((phenylmethoxycarbonyl)amino)-4-cyanobutanoic acid; With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 0.166667h;

ethanol; In tetrahydrofuran; for 16h; Heating / reflux;

upstream raw materials:

N₂-benzyloxycarbonyl-l-glutamine ethyl ester

Cbz-L-Gln

ethanol

(S)-2-((phenylmethoxycarbonyl)amino)-4-cyanobutanoic acid

Downstream raw materials:

ethyl (S)-2-[(benzyloxycarbonyl)(methyl)amino]-4-cyanobutanoate

(S)-6-amino-3-[(benzyloxycarbonyl)(methyl)amino]-2,3,4,5-tetrahydropyridin-2-one

5-benzyloxycarbonylimino-1-methyl-L-proline amide

C₂₃H₂₄N₄O₆