benzyl 2-(4-(3-amino-6-(3-[(2,3-dihydro-2,2,4,6,7-pentamethyl-2H-1-benzofuran-5-yl)sulfonyl]guanidino)-1-aza-2-oxohexan-1-yl)tetrahydro-2H-pyran-4-yl)acetate

Base Information

Chemical Name:benzyl 2-(4-(3-amino-6-(3-[(2,3-dihydro-2,2,4,6,7-pentamethyl-2H-1-benzofuran-5-yl)sulfonyl]guanidino)-1-aza-2-oxohexan-1-yl)tetrahydro-2H-pyran-4-yl)acetate
CAS No.:1413936-82-9
Molecular Formula:C₃₃H₄₇N₅O₇S
Molecular Weight:657.831
Hs Code.:

benzyl 2-(4-(3-amino-6-(3-[(2,3-dihydro-2,2,4,6,7-pentamethyl-2H-1-benzofuran-5-yl)sulfonyl]guanidino)-1-aza-2-oxohexan-1-yl)tetrahydro-2H-pyran-4-yl)acetate

Synonyms:benzyl 2-(4-(3-amino-6-(3-[(2,3-dihydro-2,2,4,6,7-pentamethyl-2H-1-benzofuran-5-yl)sulfonyl]guanidino)-1-aza-2-oxohexan-1-yl)tetrahydro-2H-pyran-4-yl)acetate

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Chemical Property of benzyl 2-(4-(3-amino-6-(3-[(2,3-dihydro-2,2,4,6,7-pentamethyl-2H-1-benzofuran-5-yl)sulfonyl]guanidino)-1-aza-2-oxohexan-1-yl)tetrahydro-2H-pyran-4-yl)acetate

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Technology Process of benzyl 2-(4-(3-amino-6-(3-[(2,3-dihydro-2,2,4,6,7-pentamethyl-2H-1-benzofuran-5-yl)sulfonyl]guanidino)-1-aza-2-oxohexan-1-yl)tetrahydro-2H-pyran-4-yl)acetate

There total 5 articles about benzyl 2-(4-(3-amino-6-(3-[(2,3-dihydro-2,2,4,6,7-pentamethyl-2H-1-benzofuran-5-yl)sulfonyl]guanidino)-1-aza-2-oxohexan-1-yl)tetrahydro-2H-pyran-4-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1413936-81-8
C₄₈H₅₇N₅O₉S

: 1413936-82-9
benzyl 2-(4-(3-amino-6-(3-[(2,3-dihydro-2,2,4,6,7-pentamethyl-2H-1-benzofuran-5-yl)sulfonyl]guanidino)-1-aza-2-oxohexan-1-yl)tetrahydro-2H-pyran-4-yl)acetate

Guidance literature:: With piperidine; In acetonitrile; at 20 ℃; for 3h;
DOI:10.3762/bjoc.8.142

Reference yield:

: 946682-30-0
2-(4-(tert-butoxycarbonylamino)tetrahydro-2H-pyran-4-yl)acetic acid

: 1413936-82-9
benzyl 2-(4-(3-amino-6-(3-[(2,3-dihydro-2,2,4,6,7-pentamethyl-2H-1-benzofuran-5-yl)sulfonyl]guanidino)-1-aza-2-oxohexan-1-yl)tetrahydro-2H-pyran-4-yl)acetate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / tetrahydrofuran / 3 h / Reflux

2: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / acetonitrile / 20 °C

4: piperidine / acetonitrile / 3 h / 20 °C

With piperidine; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.3762/bjoc.8.142

Reference yield:

: 1413936-79-4
benzyl 2-(4-(tert-butoxycarbonylamino) tetrahydro-2H-pyran-4-yl)acetate

: 1413936-82-9
benzyl 2-(4-(3-amino-6-(3-[(2,3-dihydro-2,2,4,6,7-pentamethyl-2H-1-benzofuran-5-yl)sulfonyl]guanidino)-1-aza-2-oxohexan-1-yl)tetrahydro-2H-pyran-4-yl)acetate

Guidance literature:: Multi-step reaction with 3 steps

1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / acetonitrile / 20 °C

3: piperidine / acetonitrile / 3 h / 20 °C

With piperidine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; acetonitrile;
DOI:10.3762/bjoc.8.142