(2-benzylcarbamoyl-ethyl)-carbamic acid 9H-fluoren-9-ylmethyl ester

Base Information

• Chemical Name: (2-benzylcarbamoyl-ethyl)-carbamic acid 9H-fluoren-9-ylmethyl ester
• CAS No.: 219803-84-6
• Molecular Formula: C₂₅H₂₄N₂O₃
• Molecular Weight: 400.477
• Mol file: 219803-84-6.mol

Synonyms:(2-benzylcarbamoyl-ethyl)-carbamic acid 9H-fluoren-9-ylmethyl ester

Chemical Property of (2-benzylcarbamoyl-ethyl)-carbamic acid 9H-fluoren-9-ylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of (2-benzylcarbamoyl-ethyl)-carbamic acid 9H-fluoren-9-ylmethyl ester

There total 1 articles about (2-benzylcarbamoyl-ethyl)-carbamic acid 9H-fluoren-9-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-Fmoc-β-alanine (35737-10-1) + benzylamine (100-46-9) → (2-benzylcarbamoyl-ethyl)-carbamic acid 9H-fluoren-9-ylmethyl ester (219803-84-6)

Guidance literature:

Yield given; Multistep reaction; solid phase synthesis on various solid supports and linkers;

DOI:10.1016/S0040-4039(98)02085-1

Reference yield:

(2-benzylcarbamoyl-ethyl)-carbamic acid 9H-fluoren-9-ylmethyl ester (219803-84-6) → β-alanine benzylamide (64018-20-8)

Guidance literature:

With piperidine; In N,N-dimethyl-formamide; for 0.666667h;

DOI:10.1002/anie.200462595

Reference yield:

(2-benzylcarbamoyl-ethyl)-carbamic acid 9H-fluoren-9-ylmethyl ester (219803-84-6) → {(2R,3R,4R,5R,6R)-2-(2-Benzylcarbamoyl-ethylcarbamoyl)-6-[(9H-fluoren-9-ylmethoxycarbonylamino)-methyl]-4,5-bis-methoxymethoxy-tetrahydro-pyran-3-yl}-carbamic acid tert-butyl ester (852873-25-7)

Guidance literature:

Multi-step reaction with 2 steps

1: piperidine / dimethylformamide / 0.67 h

2: 2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium*PF₆; 1-hydroxybenzotriazole; iPr₂NEt / dimethylformamide; CHCl₃

With piperidine; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In chloroform; N,N-dimethyl-formamide;

DOI:10.1002/anie.200462595

upstream raw materials:

N-Fmoc-β-alanine

benzylamine

Downstream raw materials:

β-alanine benzylamide

[(2R,3R,4R,5R,6R)-6-Azidomethyl-2-(2-benzylcarbamoyl-ethylcarbamoyl)-4,5-bis-methoxymethoxy-tetrahydro-pyran-3-yl]-carbamic acid 9H-fluoren-9-ylmethyl ester

{(2R,3R,4R,5R,6R)-2-(2-Benzylcarbamoyl-ethylcarbamoyl)-6-[(9H-fluoren-9-ylmethoxycarbonylamino)-methyl]-4,5-bis-methoxymethoxy-tetrahydro-pyran-3-yl}-carbamic acid tert-butyl ester

{2-[6-azidomethyl-2-(2-benzylcarbamoyl-ethylcarbamoyl)-4,5-bis-methoxymethoxy-tetrahydro-pyran-3-ylcarbamoyl]-6-[(9H-fluoren-9-ylmethoxycarbonylamino)-methyl]-4,5-bis-methoxymethoxy-tetrahydro-pyran-3-yl}-carbamic acid tert-butyl ester