C₂₁H₂₀O₄

Base Information

• Chemical Name: C₂₁H₂₀O₄
• CAS No.: 1276122-32-7
• Molecular Formula: C₂₁H₂₀O₄
• Molecular Weight: 336.387
• Mol file: 1276122-32-7.mol

Synonyms:C₂₁H₂₀O₄

Chemical Property of C₂₁H₂₀O₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₁H₂₀O₄

There total 2 articles about C₂₁H₂₀O₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

C20H18O4 (1308769-93-8) + methyl iodide (74-88-4) → C21H20O4 (1276122-32-7)

Guidance literature:

With potassium carbonate; In acetone; at 56 ℃; for 2h;

DOI:10.1016/j.tetlet.2011.01.011

Reference yield:

C27H22O5 (1276122-29-2) → C21H20O4 (1276122-32-7)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium tert-butylate / toluene / 3 h / 110 °C

2: potassium carbonate / acetone / 2 h / 56 °C

With potassium tert-butylate; potassium carbonate; In acetone; toluene; 1: Garratt-Braverman cyclization;

DOI:10.1016/j.tetlet.2011.01.011

Reference yield:

C21H20O4 (1276122-32-7) → 6,7-dimethoxy-9-(4-methoxyphenyl)naphtho[2,3-c]furan-1(3H)-one (145726-16-5) + 6,7-Dimethoxy-4-(4-methoxy-phenyl)-3H-naphtho[2,3-c]furan-1-one

Guidance literature:

With potassium permanganate; copper(ll) sulfate pentahydrate; In dichloromethane; for 72h; Reflux;

DOI:10.1016/j.tetlet.2011.01.011

upstream raw materials:

C₂₇H₂₂O₅

C₂₀H₁₈O₄

methyl iodide

Downstream raw materials:

6,7-dimethoxy-9-(4-methoxyphenyl)naphtho[2,3-c]furan-1(3H)-one

Refernces