5,6-DIMETHOXYISOINDOLINE

Base Information

• Chemical Name: 5,6-DIMETHOXYISOINDOLINE
• CAS No.: 114041-16-6
• Molecular Formula: C10H13 N O2
• Molecular Weight: 179.22
• Hs Code.: 2933990090
• Mol file: 114041-16-6.mol

Synonyms:5,6-Dimethoxyisoindoline

Chemical Property of 5,6-DIMETHOXYISOINDOLINE

Chemical Property:

• Boiling Point: 287.3±40.0 °C(Predicted)
• PKA: 8.34±0.20(Predicted)
• PSA: 30.49000
• Density: 1.102±0.06 g/cm3(Predicted)
• LogP: 1.63580

Purity/Quality:

98%,99%, ^*data from raw suppliers

5,6-Dimethoxyisoindoline 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5,6-DIMETHOXYISOINDOLINE

There total 5 articles about 5,6-DIMETHOXYISOINDOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.3%

2,3-Dihydro-5,6-dimethoxy-2-(phenylmethyl)-1H-isoindole (114041-14-4) + diethyl ether (60-29-7,927820-24-4) → 5,6-dimethoxyisoindoline (114041-16-6)

Guidance literature:

palladium-carbon; In methanol; ethyl acetate;

Reference yield: 69.0%

C29H27NO2 (1427927-32-9) → 5,6-dimethoxyisoindoline (114041-16-6)

Guidance literature:

With trifluoroacetic acid; In methanol; chloroform; at 0 - 20 ℃; for 1h;

DOI:10.1021/acs.jmedchem.5b01378

Reference yield:

1,2-dimethoxybenzene (91-16-7) → 5,6-dimethoxyisoindoline (114041-16-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: acetic acid; hydrogen bromide / 21 h / 20 - 65 °C

2.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 60 °C

3.1: trifluoroacetic acid / chloroform; methanol / 0 - 20 °C

3.3: pH Ca_. 10

With hydrogen bromide; acetic acid; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In methanol; chloroform; N,N-dimethyl-formamide;

upstream raw materials:

2,3-Dihydro-5,6-dimethoxy-2-(phenylmethyl)-1H-isoindole

diethyl ether

1,2-dimethoxybenzene

1,2-bis(bromomethyl)-4,5-dimethoxybenzene

Downstream raw materials:

(1R,2R)-2-(5,6-dimethoxy-1,3-dihydro-isoindole-2-carbonyl)cyclohexanecarboxylic acid (1-cyano-cyclopropyl)amide

1-(5,6-dimethoxyisoindolin-2-yl)-6-[4-(3-trifluoromethylphenyl)piperazin-1-yl]hexan-1-one

Refernces

• 1、 -. "COMPOSITIONS AND METHODS FOR TREATING CANCER". . . Retrieved 2013/03/28.
• 2、 -. "Process for the production of isoindoline derivatives, novel intermediates and process for their production". . . Retrieved 2008/06/13.