1-phenyl-5-trifluoromethyl-1H-pyrazole-4-carboxylic acid{3-fluoro-4-[3-(4-methoxybenzyl)-2-oxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidin-5-yloxy]phenyl}amide

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Chemical Name:1-phenyl-5-trifluoromethyl-1H-pyrazole-4-carboxylic acid{3-fluoro-4-[3-(4-methoxybenzyl)-2-oxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidin-5-yloxy]phenyl}amide
CAS No.:1422264-05-8
Molecular Formula:C₃₂H₂₄F₄N₆O₄
Molecular Weight:632.574
Hs Code.:

1-phenyl-5-trifluoromethyl-1H-pyrazole-4-carboxylic acid{3-fluoro-4-[3-(4-methoxybenzyl)-2-oxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidin-5-yloxy]phenyl}amide

Synonyms:1-phenyl-5-trifluoromethyl-1H-pyrazole-4-carboxylic acid{3-fluoro-4-[3-(4-methoxybenzyl)-2-oxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidin-5-yloxy]phenyl}amide

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Chemical Property of 1-phenyl-5-trifluoromethyl-1H-pyrazole-4-carboxylic acid{3-fluoro-4-[3-(4-methoxybenzyl)-2-oxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidin-5-yloxy]phenyl}amide

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Technology Process of 1-phenyl-5-trifluoromethyl-1H-pyrazole-4-carboxylic acid{3-fluoro-4-[3-(4-methoxybenzyl)-2-oxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidin-5-yloxy]phenyl}amide

There total 6 articles about 1-phenyl-5-trifluoromethyl-1H-pyrazole-4-carboxylic acid{3-fluoro-4-[3-(4-methoxybenzyl)-2-oxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidin-5-yloxy]phenyl}amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1265635-29-7
5-(4-amino-2-fluorophenoxy)-3-(4-methoxybenzyl)-3,4-dihydropyrido[2,3-d]pyrimidin-2(1H)-one

: 98534-81-7
1-phenyl-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

: 1422264-05-8
1-phenyl-5-trifluoromethyl-1H-pyrazole-4-carboxylic acid{3-fluoro-4-[3-(4-methoxybenzyl)-2-oxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidin-5-yloxy]phenyl}amide

Guidance literature:: 1-phenyl-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid; With thionyl chloride; In dichloromethane; for 1h; Reflux;

5-(4-amino-2-fluorophenoxy)-3-(4-methoxybenzyl)-3,4-dihydropyrido[2,3-d]pyrimidin-2(1H)-one; In pyridine; at 20 ℃; for 1h;

Reference yield:

: 1265634-73-8
5-chloro-3-(4-methoxy-benzyl)-3,4-dihydro-1h-pyrido[2,3-d]pyrimidin-2-one

: 1422264-05-8
1-phenyl-5-trifluoromethyl-1H-pyrazole-4-carboxylic acid{3-fluoro-4-[3-(4-methoxybenzyl)-2-oxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidin-5-yloxy]phenyl}amide

Guidance literature:: Multi-step reaction with 2 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 4 h / 150 °C

2.1: thionyl chloride / dichloromethane / 1 h / Reflux

2.2: 1 h / 20 °C

With thionyl chloride; caesium carbonate; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1265637-60-2
tert-butyl 4-chloro-3-((4-methoxybenzylamino)methyl) pyridin-2-ylcarbamate

: 1422264-05-8
1-phenyl-5-trifluoromethyl-1H-pyrazole-4-carboxylic acid{3-fluoro-4-[3-(4-methoxybenzyl)-2-oxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidin-5-yloxy]phenyl}amide

Guidance literature:: Multi-step reaction with 4 steps

1.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

2.1: acetonitrile / 24 h / 20 °C

3.1: caesium carbonate / N,N-dimethyl-formamide / 4 h / 150 °C

4.1: thionyl chloride / dichloromethane / 1 h / Reflux

4.2: 1 h / 20 °C

With thionyl chloride; caesium carbonate; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;