2-(2-chloropyridin-4-yl)-1-(3-methoxy-5-methylphenyl)ethanone

Base Information

• Chemical Name: 2-(2-chloropyridin-4-yl)-1-(3-methoxy-5-methylphenyl)ethanone
• CAS No.: 1217181-38-8
• Molecular Formula: C₁₅H₁₄ClNO₂
• Molecular Weight: 275.735
• Mol file: 1217181-38-8.mol

Synonyms:2-(2-chloropyridin-4-yl)-1-(3-methoxy-5-methylphenyl)ethanone

Chemical Property of 2-(2-chloropyridin-4-yl)-1-(3-methoxy-5-methylphenyl)ethanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2-chloropyridin-4-yl)-1-(3-methoxy-5-methylphenyl)ethanone

There total 3 articles about 2-(2-chloropyridin-4-yl)-1-(3-methoxy-5-methylphenyl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2-chloro-4-methylpyrimidine (13036-57-2) + methyl 3-methoxy-5-methylbenzoate (108593-44-8) → 2-(2-chloropyridin-4-yl)-1-(3-methoxy-5-methylphenyl)ethanone (1217181-38-8)

Guidance literature:

With lithium hexamethyldisilazane; In tetrahydrofuran; at 20 ℃; for 18h; Inert atmosphere;

DOI:10.3390/molecules20011031

Reference yield: 72.0%

2-chloro-4-picoline (3678-62-4) + methyl 3-methoxy-5-methylbenzoate (108593-44-8) → 2-(2-chloropyridin-4-yl)-1-(3-methoxy-5-methylphenyl)ethanone (1217181-38-8)

Guidance literature:

2-chloro-4-picoline; With lithium hexamethyldisilazane; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

methyl 3-methoxy-5-methylbenzoate; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

DOI:10.1016/j.bmcl.2009.08.029

Reference yield:

3-hydroxy-5-methylbenzoic acid (585-81-9) → 2-(2-chloropyridin-4-yl)-1-(3-methoxy-5-methylphenyl)ethanone (1217181-38-8)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / dmap / acetone / 12 h / 65 °C

2: lithium hexamethyldisilazane / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

With potassium carbonate; lithium hexamethyldisilazane; dmap; In tetrahydrofuran; acetone;

upstream raw materials:

2-chloro-4-picoline

methyl 3-methoxy-5-methylbenzoate

3-hydroxy-5-methylbenzoic acid

2-chloro-4-methylpyrimidine

Downstream raw materials:

2-(4-(2-chloropyridin-4-yl)-5-(3-methoxy-5-methylphenyl)-1H-pyrazol-1-yl)acetonitrile

2-(4-(2-chloropyridin-4-yl)-3-(3-methoxy-5-methylphenyl)-1H-pyrazol-1-yl)acetonitrile

2-(3-(3-methoxy-5-methylphenyl)-4-(2-phenylpyridin-4-yl)-1H-pyrazol-1-yl)acetonitrile

[3-(3-methoxy-5-methylphenyl)-4-(2-(pyridin-3-yl)pyridin-4-yl)-pyrazol-1-yl]acetonitrile