5-(3-(ethylsulfonyl)phenyl)-3,8-dimethyl-7-(trifluoromethyl)-9H-pyrido[2,3-b]indole monoacetate

Base Information

Chemical Name:5-(3-(ethylsulfonyl)phenyl)-3,8-dimethyl-7-(trifluoromethyl)-9H-pyrido[2,3-b]indole monoacetate
CAS No.:1191889-30-1
Molecular Formula:C₂H₄O₂*C₂₂H₁₉F₃N₂O₂S
Molecular Weight:492.519
Hs Code.:

Synonyms:5-(3-(ethylsulfonyl)phenyl)-3,8-dimethyl-7-(trifluoromethyl)-9H-pyrido[2,3-b]indole monoacetate

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Chemical Property of 5-(3-(ethylsulfonyl)phenyl)-3,8-dimethyl-7-(trifluoromethyl)-9H-pyrido[2,3-b]indole monoacetate

Chemical Property:

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Technology Process of 5-(3-(ethylsulfonyl)phenyl)-3,8-dimethyl-7-(trifluoromethyl)-9H-pyrido[2,3-b]indole monoacetate

There total 5 articles about 5-(3-(ethylsulfonyl)phenyl)-3,8-dimethyl-7-(trifluoromethyl)-9H-pyrido[2,3-b]indole monoacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 934542-74-2
3'-(ethylsulfonyl)-2-(2-fluoro-5-methylpyridin-3-yl)-4-methyl-5-(trifluoromethyl)biphenyl-3-amine

: 64-19-7,77671-22-8
acetic acid

: 1191889-30-1
5-(3-(ethylsulfonyl)phenyl)-3,8-dimethyl-7-(trifluoromethyl)-9H-pyrido[2,3-b]indole monoacetate

Guidance literature:: for 3h; Reflux;

Reference yield:

: 115571-66-9
2,3-dichloro-5-trifluoromethyl-6-methylnitrobenzene

: 1191889-30-1
5-(3-(ethylsulfonyl)phenyl)-3,8-dimethyl-7-(trifluoromethyl)-9H-pyrido[2,3-b]indole monoacetate

Guidance literature:: Multi-step reaction with 4 steps

1: copper / 1-methyl-pyrrolidin-2-one / 2 h / 190 °C

2: caesium carbonate / bis(dibenzylideneacetone)-palladium⁽⁰⁾; tricyclohexylphosphine / 1,4-dioxane / 4.5 h / Reflux

3: iron; acetic acid / water / 2 h / 80 °C

4: 3 h / Reflux

With iron; copper; caesium carbonate; acetic acid; bis(dibenzylideneacetone)-palladium⁽⁰⁾; tricyclohexylphosphine; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; water;

Reference yield:

: 934542-72-0
3-(6-chloro-3-methyl-2-nitro-4-(trifluoromethyl)phenyl)-2-fluoro-5-methylpyridine

: 1191889-30-1
5-(3-(ethylsulfonyl)phenyl)-3,8-dimethyl-7-(trifluoromethyl)-9H-pyrido[2,3-b]indole monoacetate

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate / bis(dibenzylideneacetone)-palladium⁽⁰⁾; tricyclohexylphosphine / 1,4-dioxane / 4.5 h / Reflux

2: iron; acetic acid / water / 2 h / 80 °C

3: 3 h / Reflux

With iron; caesium carbonate; acetic acid; bis(dibenzylideneacetone)-palladium⁽⁰⁾; tricyclohexylphosphine; In 1,4-dioxane; water;