5-ethoxycarbonyl-6-methyl-4-(4-methoxyphenyl)-2-(2-hydroxy-2-phenylvinyl)-1,4-dihydropyrimidine

Base Information

Chemical Name:5-ethoxycarbonyl-6-methyl-4-(4-methoxyphenyl)-2-(2-hydroxy-2-phenylvinyl)-1,4-dihydropyrimidine
CAS No.:1149335-25-0
Molecular Formula:C₂₃H₂₄N₂O₄
Molecular Weight:392.455
Hs Code.:

Synonyms:5-ethoxycarbonyl-6-methyl-4-(4-methoxyphenyl)-2-(2-hydroxy-2-phenylvinyl)-1,4-dihydropyrimidine

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Chemical Property of 5-ethoxycarbonyl-6-methyl-4-(4-methoxyphenyl)-2-(2-hydroxy-2-phenylvinyl)-1,4-dihydropyrimidine

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Technology Process of 5-ethoxycarbonyl-6-methyl-4-(4-methoxyphenyl)-2-(2-hydroxy-2-phenylvinyl)-1,4-dihydropyrimidine

There total 3 articles about 5-ethoxycarbonyl-6-methyl-4-(4-methoxyphenyl)-2-(2-hydroxy-2-phenylvinyl)-1,4-dihydropyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 113697-57-7
5-(ethoxycarbonyl)-4-(4-methoxyphenyl)-6-methyl-3,4-dihydropyrimidin-2(1H)-thione

: 70-11-1
α-bromoacetophenone

: 1149335-25-0
5-ethoxycarbonyl-6-methyl-4-(4-methoxyphenyl)-2-(2-hydroxy-2-phenylvinyl)-1,4-dihydropyrimidine

Guidance literature:: 5-(ethoxycarbonyl)-4-(4-methoxyphenyl)-6-methyl-3,4-dihydropyrimidin-2(1H)-thione; α-bromoacetophenone; With potassium carbonate; In acetone; at 25 ℃; for 0.5h;

In acetone; at 80 ℃; for 10h;
DOI:10.1016/j.tetlet.2009.02.027

Reference yield:

: 938009-47-3
C₂₃H₂₄N₂O₄S

: 1149335-25-0
5-ethoxycarbonyl-6-methyl-4-(4-methoxyphenyl)-2-(2-hydroxy-2-phenylvinyl)-1,4-dihydropyrimidine

Guidance literature:: With triisopropyl phosphite; In 1,4-dioxane; at 220 ℃; for 0.0194444h; under 75007.5 Torr;
DOI:10.3762/bjoc.7.135

Reference yield:

: 113697-57-7
ethyl 2-mercapto-4-(4-methoxyphenyl)-6-methyl-1,4-dihydropyrimidine-5-carboxylate

: 1149335-25-0
5-ethoxycarbonyl-6-methyl-4-(4-methoxyphenyl)-2-(2-hydroxy-2-phenylvinyl)-1,4-dihydropyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / 1,4-dioxane / 1 h / Sonication; Heating

2: triisopropyl phosphite / 1,4-dioxane / 0.02 h / 220 °C / 75007.5 Torr

With triisopropyl phosphite; triethylamine; In 1,4-dioxane; 2: Eschenmoser coupling;
DOI:10.3762/bjoc.7.135