ethyl (2S,2(2S))-2-azido-[(N-benzyloxycarbonyl)piperidin-2-yl]ethanoate

Base Information

Chemical Name:ethyl (2S,2(2S))-2-azido-[(N-benzyloxycarbonyl)piperidin-2-yl]ethanoate
CAS No.:260057-62-3
Molecular Formula:C₁₇H₂₂N₄O₄
Molecular Weight:346.386
Hs Code.:

Synonyms:ethyl (2S,2(2S))-2-azido-[(N-benzyloxycarbonyl)piperidin-2-yl]ethanoate

Suppliers and Price of ethyl (2S,2(2S))-2-azido-[(N-benzyloxycarbonyl)piperidin-2-yl]ethanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of ethyl (2S,2(2S))-2-azido-[(N-benzyloxycarbonyl)piperidin-2-yl]ethanoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of ethyl (2S,2(2S))-2-azido-[(N-benzyloxycarbonyl)piperidin-2-yl]ethanoate

There total 4 articles about ethyl (2S,2(2S))-2-azido-[(N-benzyloxycarbonyl)piperidin-2-yl]ethanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 260057-61-2,167170-23-2
ethyl (S)-2-[(N-benzyloxycarbonyl)piperidin-2-yl]ethanoate

: 260057-62-3
ethyl (2S,2(2S))-2-azido-[(N-benzyloxycarbonyl)piperidin-2-yl]ethanoate

: ethyl (2R,2(2S))-2-azido-[(N-benzyloxycarbonyl)piperidin-2-yl]ethanoate

Guidance literature:: With 2,4,6-Triisopropylbenzenesulfonyl azide; potassium hexamethylsilazane; In tetrahydrofuran; toluene; at -78 ℃;
DOI:10.3987/COM-99-8699

Reference yield:

: 137428-09-2
2-[(N-benzyloxycarbonyl)piperidin-2-yl]ethanoic acid

: 260057-62-3
ethyl (2S,2(2S))-2-azido-[(N-benzyloxycarbonyl)piperidin-2-yl]ethanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: Et₃N / tetrahydrofuran / -78 - 0 °C

2.1: n-BuLi / tetrahydrofuran; hexane / -78 °C

2.2: tetrahydrofuran; hexane / -78 - 20 °C

3.1: 81 percent / NaOEt / 2 h

4.1: KHMDS; trisyl azide / tetrahydrofuran; toluene / -78 °C

With n-butyllithium; 2,4,6-Triisopropylbenzenesulfonyl azide; sodium ethanolate; potassium hexamethylsilazane; triethylamine; In tetrahydrofuran; hexane; toluene; 1.1: Acylation / 2.1: Metallation / 2.2: amidation / 3.1: alkoxylation / 4.1: azidation;
DOI:10.3987/COM-99-8699

Reference yield:

: 2-[2-(2,2-dimethyl-propionyloxy)-2-oxo-ethyl]-piperidine-1-carboxylic acid benzyl ester

: 260057-62-3
ethyl (2S,2(2S))-2-azido-[(N-benzyloxycarbonyl)piperidin-2-yl]ethanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-BuLi / tetrahydrofuran; hexane / -78 °C

1.2: tetrahydrofuran; hexane / -78 - 20 °C

2.1: 81 percent / NaOEt / 2 h

3.1: KHMDS; trisyl azide / tetrahydrofuran; toluene / -78 °C

With n-butyllithium; 2,4,6-Triisopropylbenzenesulfonyl azide; sodium ethanolate; potassium hexamethylsilazane; In tetrahydrofuran; hexane; toluene; 1.1: Metallation / 1.2: amidation / 2.1: alkoxylation / 3.1: azidation;
DOI:10.3987/COM-99-8699