137428-09-2

Basic information

• Product Name: 2-CARBOXYMETHYL-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER
• Synonyms: 2-CARBOXYMETHYL-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER;N-CBZ-2-PIPERIDINEACETIC ACID;N-CARBOBENZYLOXY-2-PIPERIDINE ACETIC ACID;2-(1-((Benzyloxy)carbonyl)piperidin-2-yl)acetic acid
• CAS NO: 137428-09-2
• Molecular Formula: C15H19NO4
• Molecular Weight: 277.32
• Product Categories: pharmacetical
• Mol File: 137428-09-2.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 460.1±28.0 °C(Predicted)
• Appearance: /
• Density: 1.216±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 4.75±0.10(Predicted)
• CAS DataBase Reference: 2-CARBOXYMETHYL-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CARBOXYMETHYL-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER(137428-09-2)
• EPA Substance Registry System: 2-CARBOXYMETHYL-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER(137428-09-2)

Safety Data

• Hazardous Substances Data: 137428-09-2(Hazardous Substances Data)

Usage

General Description

2-CARBOXYMETHYL-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER is a chemical compound with the molecular formula C17H23NO4. It is an ester derivative of carboxymethyl-piperidine-carboxylic acid and benzyl alcohol. 2-CARBOXYMETHYL-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER is commonly used as an intermediate in the synthesis of pharmaceuticals and other organic compounds. It has potential applications in the pharmaceutical industry for the development of new drugs and therapeutic agents. The benzyl ester group in this compound makes it a versatile starting material for the synthesis of various organic compounds, making it an important building block in chemical synthesis.

Upstream product

• 260057-58-7 (3(2(2S)),4S,5R)-3-[2-((N-benzyloxycarbonyl)piperidin-2-yl)-1-oxoethyl]-4-methyl-5-phenyl-2-oxazolidinone 
• 501-53-1 benzyl chloroformate 
• 542-05-2 acetonedicarboxylic acid 
• 1369774-33-3 (1R,5R)-9-benzyloxycarbonylamino-2-oxo-1-oxabicyclo[3.3.1]nonane 
• 1369774-32-2 7-benzyloxycarbonylazabicyclo-[3.2.1]octan-6-one 
• 1369774-31-1 (1R,5S,6S)-N-benzyloxycarbonyl-6-tropanol 
• 1369774-30-0 (1R,5S,6R)-6-tropanol 
• 1369774-34-4 (1R,5S,6R)-6-tropanol (R,R)-tartrate 
• 1369774-29-7 6-tropanol 
• 19832-04-3 (R)-2-(piperidin-2'-yl)ethanoic acid 
• 143264-57-7 (R)-1-(benzyloxycarbonyl)-2-(2-oxoethyl)piperidine 
• 260057-57-6 (3(2(2R)),4S,5R)-3-[2-((N-benzyloxycarbonyl)piperidin-2-yl)-1-oxoethyl]-4-methyl-5-phenyl-2-oxazolidinone 
• 39945-50-1 2-(2-hydroxyethyl)-piperidine-1-carboxylic acid benzyl ester 
• 1484-84-0 2(RS)-(2-hydroxyethyl)piperidine 

Downstream Products

• 64625-19-0 (S)-2-(piperidin-2-yl)ethanoic acid 
• 19832-04-3 (R)-2-(piperidin-2'-yl)ethanoic acid 
• 260057-64-5 (2S,2(2S))-2-amino-2-(piperidin-2-yl)ethanoic acid 
• 260057-64-5 (2S,2(2R))-2-amino-2-(piperidin-2-yl)ethanoic acid 

Relevant articles and documents

Synthesis of dendrobatid alkaloid (+)-167B and (+)-209D and the investigation of diastereoselectivity using DFT calculations

The synthesis of dendrobatid alkaloid (+)-167B and (+)-209D has been developed on the basis of the effective preparation of chiral tropinone 7-azabicyclo[3.2.1]octan-6-ol. DFT calculations have been applied to explain the observed diastereoselectivity.

Syntheses of (-)-pelletierine and (-)-homopipecolic acid

Enantiomeric syntheses of (-)-homopipecolic acid and (-)-pelletierine have been achieved by chiral resolution of tropanol followed by Baeyer-Villiger oxidation. The methodology provides a practical route for the synthesis of optically pure piperidines. The Royal Society of Chemistry 2012.

Improved protocol for asymmetric, intramolecular heteroatom Michael addition using organocatalysis: Enantioselective syntheses of homoproline, pelletierine, and homopipecolic acid

(Chemical Equation Presented) An improved protocol for the construction of enantioenriched pyrrolidine, indoline, and piperidine rings using an organocatalyzed, intramolecular heteroatom Michael addition is described. Application to the enantioselective synthesis of homoproline, homopipecolic acid, and pelletierine has been accomplished.