137428-09-2

Basic information

• Product Name: 2-CARBOXYMETHYL-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER
• Synonyms: 2-CARBOXYMETHYL-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER;N-CBZ-2-PIPERIDINEACETIC ACID;N-CARBOBENZYLOXY-2-PIPERIDINE ACETIC ACID;2-(1-((Benzyloxy)carbonyl)piperidin-2-yl)acetic acid
• CAS NO: 137428-09-2
• Molecular Formula: C15H19NO4
• Molecular Weight: 277.32
• Product Categories: pharmacetical
• Mol File: 137428-09-2.mol

Chemical Properties

• Boiling Point: 460.1±28.0 °C(Predicted)
• Appearance: /
• Density: 1.216±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 4.75±0.10(Predicted)
• CAS DataBase Reference: 2-CARBOXYMETHYL-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CARBOXYMETHYL-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER(137428-09-2)
• EPA Substance Registry System: 2-CARBOXYMETHYL-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER(137428-09-2)

Safety Data

• Hazardous Substances Data: 137428-09-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-CARBOXYMETHYL-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER is used as an intermediate in the synthesis of pharmaceuticals for its potential role in the development of new drugs and therapeutic agents. Its unique structure allows for the creation of a variety of organic compounds, making it a valuable building block in the synthesis of medicinally relevant molecules.
Used in Organic Synthesis:
In the field of organic synthesis, 2-CARBOXYMETHYL-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER is used as a versatile starting material for the synthesis of various organic compounds. The benzyl ester group in this compound provides a foundation for further chemical reactions, facilitating the creation of a wide range of chemical entities for research and commercial purposes.

Upstream product

• 1484-84-0 2(RS)-(2-hydroxyethyl)piperidine 
• 501-53-1 benzyl chloroformate 
• 39945-50-1 2-(2-hydroxyethyl)-piperidine-1-carboxylic acid benzyl ester 
• 260057-57-6 (3(2(2R)),4S,5R)-3-[2-((N-benzyloxycarbonyl)piperidin-2-yl)-1-oxoethyl]-4-methyl-5-phenyl-2-oxazolidinone 
• 143264-57-7 (R)-1-(benzyloxycarbonyl)-2-(2-oxoethyl)piperidine 
• 19832-04-3 (R)-2-(piperidin-2'-yl)ethanoic acid 
• 1369774-29-7 6-tropanol 
• 1369774-34-4 (1R,5S,6R)-6-tropanol (R,R)-tartrate 
• 1369774-30-0 (1R,5S,6R)-6-tropanol 
• 1369774-31-1 (1R,5S,6S)-N-benzyloxycarbonyl-6-tropanol 
• 1369774-32-2 7-benzyloxycarbonylazabicyclo-[3.2.1]octan-6-one 
• 1369774-33-3 (1R,5R)-9-benzyloxycarbonylamino-2-oxo-1-oxabicyclo[3.3.1]nonane 
• 542-05-2 acetonedicarboxylic acid 
• 260057-58-7 (3(2(2S)),4S,5R)-3-[2-((N-benzyloxycarbonyl)piperidin-2-yl)-1-oxoethyl]-4-methyl-5-phenyl-2-oxazolidinone 

Downstream Products

• 64625-19-0 (S)-2-(piperidin-2-yl)ethanoic acid 
• 19832-04-3 (R)-2-(piperidin-2'-yl)ethanoic acid 
• 260057-64-5 (2S,2(2S))-2-amino-2-(piperidin-2-yl)ethanoic acid 
• 260057-64-5 (2S,2(2R))-2-amino-2-(piperidin-2-yl)ethanoic acid 

Relevant articles and documents

Synthesis of dendrobatid alkaloid (+)-167B and (+)-209D and the investigation of diastereoselectivity using DFT calculations

The synthesis of dendrobatid alkaloid (+)-167B and (+)-209D has been developed on the basis of the effective preparation of chiral tropinone 7-azabicyclo[3.2.1]octan-6-ol. DFT calculations have been applied to explain the observed diastereoselectivity.

METHYL OXAZOLE OREXIN RECEPTOR ANTAGONISTS

The present invention is directed to methyl oxazole compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which orexin receptors are involved.

Syntheses of (-)-pelletierine and (-)-homopipecolic acid

Enantiomeric syntheses of (-)-homopipecolic acid and (-)-pelletierine have been achieved by chiral resolution of tropanol followed by Baeyer-Villiger oxidation. The methodology provides a practical route for the synthesis of optically pure piperidines. The Royal Society of Chemistry 2012.

Hydroformylation of alkenylamines. Concise approaches toward piperidines, quinolizidines, and related alkaloids

Linear hydroformylation of N-protected allyl- or homoallylamines (cyclohydrocarbonylation: CHC), followed by a reductive amination constitute the two key steps toward convenient routes to aza-heterocycles.

Improved protocol for asymmetric, intramolecular heteroatom Michael addition using organocatalysis: Enantioselective syntheses of homoproline, pelletierine, and homopipecolic acid

(Chemical Equation Presented) An improved protocol for the construction of enantioenriched pyrrolidine, indoline, and piperidine rings using an organocatalyzed, intramolecular heteroatom Michael addition is described. Application to the enantioselective synthesis of homoproline, homopipecolic acid, and pelletierine has been accomplished.

Synthesis of optically active 2-piperidylglycine

Both chiral threo- and erythro-2-piperidylglycines were synthesized from racemic 2-[(N-benzyloxycarbonyl)piperidin-2-yl]ethanoic acid. (4S,5S)-4- Methyl-5-phenyl-2-oxa-zolidinone was used as a chiral auxiliary in the resolution and azidation.