2-[3-(4-Chloro-phenyl)-ureido]-5-oxo-5-pyrrolidin-1-yl-pentanoic acid dipentylamide

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Chemical Name:2-[3-(4-Chloro-phenyl)-ureido]-5-oxo-5-pyrrolidin-1-yl-pentanoic acid dipentylamide
CAS No.:123540-71-6
Molecular Formula:C₂₆H₄₁ClN₄O₃
Molecular Weight:493.09
Hs Code.:

Synonyms:2-[3-(4-Chloro-phenyl)-ureido]-5-oxo-5-pyrrolidin-1-yl-pentanoic acid dipentylamide

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Chemical Property of 2-[3-(4-Chloro-phenyl)-ureido]-5-oxo-5-pyrrolidin-1-yl-pentanoic acid dipentylamide

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Technology Process of 2-[3-(4-Chloro-phenyl)-ureido]-5-oxo-5-pyrrolidin-1-yl-pentanoic acid dipentylamide

There total 3 articles about 2-[3-(4-Chloro-phenyl)-ureido]-5-oxo-5-pyrrolidin-1-yl-pentanoic acid dipentylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 123-75-1
pyrrolidine

: 117997-60-1
(RS)-4-[(4-chlorophenylaminocarbonyl)amino]-5-(dipentylamino)-5-oxo-pentanoic acid

: 123540-71-6
2-[3-(4-Chloro-phenyl)-ureido]-5-oxo-5-pyrrolidin-1-yl-pentanoic acid dipentylamide

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; for 48h; Ambient temperature;
DOI:10.1021/jm00164a020

Reference yield:

: 117997-81-6
5-(benzyloxy)-2-(tert-butoxycarbonylamino)-5-oxopentanoic acid

: 123540-71-6
2-[3-(4-Chloro-phenyl)-ureido]-5-oxo-5-pyrrolidin-1-yl-pentanoic acid dipentylamide

Guidance literature:: Multi-step reaction with 5 steps

1: 48 percent / 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride / CH₂Cl₂ / pH >8.5

2: 75 percent / HCl gas / ethyl acetate / 0.33 h / -25 °C

3: 84 percent / Et₃N / tetrahydrofuran / 24 h / Ambient temperature

4: 85 percent / 2.5 N NaOH / tetrahydrofuran

5: 37 percent / 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride / dimethylformamide / 48 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm00164a020

Reference yield:

: 118100-26-8
N^α-Boc-ε-benzyl-DL-glutamic acid dipentylamide

: 123540-71-6
2-[3-(4-Chloro-phenyl)-ureido]-5-oxo-5-pyrrolidin-1-yl-pentanoic acid dipentylamide

Guidance literature:: Multi-step reaction with 4 steps

1: 75 percent / HCl gas / ethyl acetate / 0.33 h / -25 °C

2: 84 percent / Et₃N / tetrahydrofuran / 24 h / Ambient temperature

3: 85 percent / 2.5 N NaOH / tetrahydrofuran

4: 37 percent / 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride / dimethylformamide / 48 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm00164a020