7-((3aS,4R,6R,6aR)-6-(aminomethyl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)-N-(2,4-dimethoxybenzyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Base Information

Chemical Name:7-((3aS,4R,6R,6aR)-6-(aminomethyl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)-N-(2,4-dimethoxybenzyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
CAS No.:1380291-27-9
Molecular Formula:C₂₄H₃₁N₅O₄
Molecular Weight:453.541
Hs Code.:

7-((3aS,4R,6R,6aR)-6-(aminomethyl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)-N-(2,4-dimethoxybenzyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Synonyms:7-((3aS,4R,6R,6aR)-6-(aminomethyl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)-N-(2,4-dimethoxybenzyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

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Chemical Property of 7-((3aS,4R,6R,6aR)-6-(aminomethyl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)-N-(2,4-dimethoxybenzyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

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Technology Process of 7-((3aS,4R,6R,6aR)-6-(aminomethyl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)-N-(2,4-dimethoxybenzyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

There total 5 articles about 7-((3aS,4R,6R,6aR)-6-(aminomethyl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)-N-(2,4-dimethoxybenzyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 79200-57-0
(1R,2S,3R,4R)-2,3-dihydroxy-4-(hydroxylmethyl)-1-aminocyclopentan hydrochloride

: 1380291-27-9
7-((3aS,4R,6R,6aR)-6-(aminomethyl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)-N-(2,4-dimethoxybenzyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / ethanol / 23 h / Reflux

2.1: hydrogenchloride / 1,4-dioxane; water / 69.5 h / 20 °C

2.2: pH 7

3.1: toluene-4-sulfonic acid / 1.25 h

4.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0.17 h / Cooling with ice

4.2: 21 h

5.1: N-ethyl-N,N-diisopropylamine / butan-1-ol / 22 h / 80 °C

6.1: trimethylphosphane / tetrahydrofuran / 1.5 h / 0 - 20 °C

With hydrogenchloride; di-isopropyl azodicarboxylate; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trimethylphosphane; toluene-4-sulfonic acid; In tetrahydrofuran; 1,4-dioxane; ethanol; water; butan-1-ol;

Reference yield:

: 1380291-25-7
7-((3aS,4R,6R,6aR)-6-(azidomethyl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)-N-(2,4-dimethoxybenzyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

: 1380291-27-9
7-((3aS,4R,6R,6aR)-6-(aminomethyl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)-N-(2,4-dimethoxybenzyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Guidance literature:: 7-((3aS,4R,6R,6aR)-6-(azidomethyl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)-N-(2,4-dimethoxybenzyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine; With trimethylphosphane; In tetrahydrofuran; at 0 - 20 ℃; for 1.5h;

With water; In tetrahydrofuran;

Reference yield:

: 14052-82-5
4,6-dichloro-5-(2,2-diethoxyethyl)pyrimidine

: 1380291-27-9
7-((3aS,4R,6R,6aR)-6-(aminomethyl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)-N-(2,4-dimethoxybenzyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / ethanol / 23 h / Reflux

2.1: hydrogenchloride / 1,4-dioxane; water / 69.5 h / 20 °C

2.2: pH 7

3.1: toluene-4-sulfonic acid / 1.25 h

4.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0.17 h / Cooling with ice

4.2: 21 h

5.1: N-ethyl-N,N-diisopropylamine / butan-1-ol / 22 h / 80 °C

6.1: trimethylphosphane / tetrahydrofuran / 1.5 h / 0 - 20 °C

With hydrogenchloride; di-isopropyl azodicarboxylate; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trimethylphosphane; toluene-4-sulfonic acid; In tetrahydrofuran; 1,4-dioxane; ethanol; water; butan-1-ol;