ethyl 3-(3-((((3aR,4R,6R,6aS)-6-(4-((2,4-dimethoxybenzyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)methyl)amino)cyclobutyl)propanoate

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Chemical Name:ethyl 3-(3-((((3aR,4R,6R,6aS)-6-(4-((2,4-dimethoxybenzyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)methyl)amino)cyclobutyl)propanoate
CAS No.:1380350-41-3
Molecular Formula:C₃₃H₄₅N₅O₆
Molecular Weight:607.75
Hs Code.:

ethyl 3-(3-((((3aR,4R,6R,6aS)-6-(4-((2,4-dimethoxybenzyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)methyl)amino)cyclobutyl)propanoate

Synonyms:ethyl 3-(3-((((3aR,4R,6R,6aS)-6-(4-((2,4-dimethoxybenzyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)methyl)amino)cyclobutyl)propanoate

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Chemical Property of ethyl 3-(3-((((3aR,4R,6R,6aS)-6-(4-((2,4-dimethoxybenzyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)methyl)amino)cyclobutyl)propanoate

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Technology Process of ethyl 3-(3-((((3aR,4R,6R,6aS)-6-(4-((2,4-dimethoxybenzyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)methyl)amino)cyclobutyl)propanoate

There total 9 articles about ethyl 3-(3-((((3aR,4R,6R,6aS)-6-(4-((2,4-dimethoxybenzyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)methyl)amino)cyclobutyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 79200-57-0
(1R,2S,3R,4R)-2,3-dihydroxy-4-(hydroxylmethyl)-1-aminocyclopentan hydrochloride

: 1380350-41-3
ethyl 3-(3-((((3aR,4R,6R,6aS)-6-(4-((2,4-dimethoxybenzyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)methyl)amino)cyclobutyl)propanoate

Guidance literature:: Multi-step reaction with 7 steps

1.1: triethylamine / ethanol / 23 h / Reflux

2.1: hydrogenchloride / 1,4-dioxane; water / 69.5 h / 20 °C

2.2: pH 7

3.1: toluene-4-sulfonic acid / 1.25 h

4.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0.17 h / Cooling with ice

4.2: 21 h

5.1: N-ethyl-N,N-diisopropylamine / butan-1-ol / 22 h / 80 °C

6.1: trimethylphosphane / tetrahydrofuran / 1.5 h / 0 - 20 °C

7.1: sodium tris(acetoxy)borohydride / acetic acid / 1,2-dichloro-ethane / 19 h / 20 °C

With hydrogenchloride; di-isopropyl azodicarboxylate; sodium tris(acetoxy)borohydride; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trimethylphosphane; toluene-4-sulfonic acid; acetic acid; In tetrahydrofuran; 1,4-dioxane; ethanol; water; 1,2-dichloro-ethane; butan-1-ol;

Reference yield:

: 1380290-31-2
ethyl 3-(3-oxocyclobutyl)propanoate

: 1380291-27-9
7-((3aS,4R,6R,6aR)-6-(aminomethyl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)-N-(2,4-dimethoxybenzyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

: 1380350-41-3
ethyl 3-(3-((((3aR,4R,6R,6aS)-6-(4-((2,4-dimethoxybenzyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)methyl)amino)cyclobutyl)propanoate

Guidance literature:: With sodium tris(acetoxy)borohydride; acetic acid; In 1,2-dichloro-ethane; at 20 ℃; for 19h;

Reference yield:

: 14052-82-5
4,6-dichloro-5-(2,2-diethoxyethyl)pyrimidine

: 1380350-41-3
ethyl 3-(3-((((3aR,4R,6R,6aS)-6-(4-((2,4-dimethoxybenzyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)methyl)amino)cyclobutyl)propanoate

Guidance literature:: Multi-step reaction with 7 steps

1.1: triethylamine / ethanol / 23 h / Reflux

2.1: hydrogenchloride / 1,4-dioxane; water / 69.5 h / 20 °C

2.2: pH 7

3.1: toluene-4-sulfonic acid / 1.25 h

4.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0.17 h / Cooling with ice

4.2: 21 h

5.1: N-ethyl-N,N-diisopropylamine / butan-1-ol / 22 h / 80 °C

6.1: trimethylphosphane / tetrahydrofuran / 1.5 h / 0 - 20 °C

7.1: sodium tris(acetoxy)borohydride / acetic acid / 1,2-dichloro-ethane / 19 h / 20 °C

With hydrogenchloride; di-isopropyl azodicarboxylate; sodium tris(acetoxy)borohydride; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trimethylphosphane; toluene-4-sulfonic acid; acetic acid; In tetrahydrofuran; 1,4-dioxane; ethanol; water; 1,2-dichloro-ethane; butan-1-ol;