thioacetic acid S-[bis-(4-methoxy-phenyl)-phosphinoylmethyl] ester

Base Information

• Chemical Name: thioacetic acid S-[bis-(4-methoxy-phenyl)-phosphinoylmethyl] ester
• CAS No.: 922517-75-7
• Molecular Formula: C₁₇H₁₉O₄PS
• Molecular Weight: 350.375
• Mol file: 922517-75-7.mol

Synonyms:thioacetic acid S-[bis-(4-methoxy-phenyl)-phosphinoylmethyl] ester

Chemical Property of thioacetic acid S-[bis-(4-methoxy-phenyl)-phosphinoylmethyl] ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of thioacetic acid S-[bis-(4-methoxy-phenyl)-phosphinoylmethyl] ester

There total 2 articles about thioacetic acid S-[bis-(4-methoxy-phenyl)-phosphinoylmethyl] ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

C15H16ClO3P (13685-40-0) + potassium thioacetate (10387-40-3) → thioacetic acid S-[bis-(4-methoxy-phenyl)-phosphinoylmethyl] ester (922517-75-7)

Guidance literature:

In N,N-dimethyl-formamide; for 18h;

DOI:10.1021/jo0620056

Reference yield:

4-methoxyphenyl magnesium bromide (13139-86-1) → thioacetic acid S-[bis-(4-methoxy-phenyl)-phosphinoylmethyl] ester (922517-75-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 63 percent / tetrahydrofuran / 24 h / Heating

2: 87 percent / dimethylformamide / 18 h

In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1021/jo0620056

Reference yield: 92.0%

thioacetic acid S-[bis-(4-methoxy-phenyl)-phosphinoylmethyl] ester (922517-75-7) → thioacetic acid S-{[bis-(4-methoxy-phenyl)-phosphanyl]-methyl} ester (922517-77-9)

Guidance literature:

With trichlorosilane; In chloroform; for 72h;

DOI:10.1021/jo0620056

upstream raw materials:

C₁₅H₁₆ClO₃P

potassium thioacetate

4-methoxyphenyl magnesium bromide

Downstream raw materials:

thioacetic acid S-{[bis-(4-methoxy-phenyl)-phosphanyl]-methyl} ester

di(4-methoxyphenyl)phosphinomethanethiol

2-acetylamino-thiopropionic acid S-{[bis-(4-methoxy-phenyl)-phosphanyl]-methyl} ester

2-acetylamino-3-phenyl-thiopropionic acid S-{[bis-(4-methoxy-phenyl)-phosphanyl]-methyl} ester