(AlaS,PheS,AspS)-N-9-fluorenylmethyloxycarbonyl-alanyl-phenylalanyl-β-(2-trimethylsilylethyl)-α-methyl-aspartate

Base Information

Chemical Name:(AlaS,PheS,AspS)-N-9-fluorenylmethyloxycarbonyl-alanyl-phenylalanyl-β-(2-trimethylsilylethyl)-α-methyl-aspartate
CAS No.:310904-86-0
Molecular Formula:C₃₇H₄₅N₃O₈Si
Molecular Weight:687.865
Hs Code.:

Synonyms:(AlaS,PheS,AspS)-N-9-fluorenylmethyloxycarbonyl-alanyl-phenylalanyl-β-(2-trimethylsilylethyl)-α-methyl-aspartate

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Chemical Property of (AlaS,PheS,AspS)-N-9-fluorenylmethyloxycarbonyl-alanyl-phenylalanyl-β-(2-trimethylsilylethyl)-α-methyl-aspartate

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Technology Process of (AlaS,PheS,AspS)-N-9-fluorenylmethyloxycarbonyl-alanyl-phenylalanyl-β-(2-trimethylsilylethyl)-α-methyl-aspartate

There total 5 articles about (AlaS,PheS,AspS)-N-9-fluorenylmethyloxycarbonyl-alanyl-phenylalanyl-β-(2-trimethylsilylethyl)-α-methyl-aspartate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 103321-50-2
9H-fluoren-9-ylmethyl [(1S)-2-chloro-1-methyl-oxoethyl]carbamate

: 310904-82-6
(PheS,AspS)-N-9-fluorenylmethyloxycarbonyl-phenylalanyl-β-(2-trimethylsilylethyl)-α-methyl-aspartate

: (3S,6S)-(2-trimethylsilylethyl) (3-(2,5-dioxo-6-benzyl)-piperazinyl)-ethanoate

: 310904-86-0
(AlaS,PheS,AspS)-N-9-fluorenylmethyloxycarbonyl-alanyl-phenylalanyl-β-(2-trimethylsilylethyl)-α-methyl-aspartate

Guidance literature:: (PheS,AspS)-N-9-fluorenylmethyloxycarbonyl-phenylalanyl-β-(2-trimethylsilylethyl)-α-methyl-aspartate; With 4-Aminomethylpiperidine; In chloroform; for 1.5h;

9H-fluoren-9-ylmethyl [(1S)-2-chloro-1-methyl-oxoethyl]carbamate; With sodium carbonate; In chloroform;
DOI:10.1007/s007060070065

Reference yield:

: 2916-68-9
2-(Trimethylsilyl)ethanol

: 310904-86-0
(AlaS,PheS,AspS)-N-9-fluorenylmethyloxycarbonyl-alanyl-phenylalanyl-β-(2-trimethylsilylethyl)-α-methyl-aspartate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 72 percent / 1-hydroxybenzotriazole; dicyclohexylcarbodiimide / pyridine; acetonitrile / 2 h / 0 °C

2.1: 100 percent / H₂ / Pd/C / propan-2-ol

3.1: 60 percent / aq. Na₂CO₃ / CHCl₃ / 0.67 h

4.1: 4-(aminomethyl)-piperidine / CHCl₃ / 1.5 h

4.2: 44 percent / aq. Na₂CO₃ / CHCl₃

With hydrogen; sodium carbonate; benzotriazol-1-ol; 4-Aminomethylpiperidine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In pyridine; chloroform; isopropyl alcohol; acetonitrile;
DOI:10.1007/s007060070065

Reference yield:

: 4668-42-2
(S)-2-benzyloxycarbonylamino-succinic acid 1-methyl ester

: 310904-86-0
(AlaS,PheS,AspS)-N-9-fluorenylmethyloxycarbonyl-alanyl-phenylalanyl-β-(2-trimethylsilylethyl)-α-methyl-aspartate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 72 percent / 1-hydroxybenzotriazole; dicyclohexylcarbodiimide / pyridine; acetonitrile / 2 h / 0 °C

2.1: 100 percent / H₂ / Pd/C / propan-2-ol

3.1: 60 percent / aq. Na₂CO₃ / CHCl₃ / 0.67 h

4.1: 4-(aminomethyl)-piperidine / CHCl₃ / 1.5 h

4.2: 44 percent / aq. Na₂CO₃ / CHCl₃

With hydrogen; sodium carbonate; benzotriazol-1-ol; 4-Aminomethylpiperidine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In pyridine; chloroform; isopropyl alcohol; acetonitrile;
DOI:10.1007/s007060070065