(AlaS,PheS,AspS)-alanyl-phenylalanyl-β-(2-trimethylsilylethyl)-α-methyl-aspartate

Base Information

Chemical Name:(AlaS,PheS,AspS)-alanyl-phenylalanyl-β-(2-trimethylsilylethyl)-α-methyl-aspartate
CAS No.:310904-88-2
Molecular Formula:C₂₂H₃₅N₃O₆Si
Molecular Weight:465.622
Hs Code.:

Synonyms:(AlaS,PheS,AspS)-alanyl-phenylalanyl-β-(2-trimethylsilylethyl)-α-methyl-aspartate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (AlaS,PheS,AspS)-alanyl-phenylalanyl-β-(2-trimethylsilylethyl)-α-methyl-aspartate

Chemical Property:

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Technology Process of (AlaS,PheS,AspS)-alanyl-phenylalanyl-β-(2-trimethylsilylethyl)-α-methyl-aspartate

There total 6 articles about (AlaS,PheS,AspS)-alanyl-phenylalanyl-β-(2-trimethylsilylethyl)-α-methyl-aspartate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 310904-86-0
(AlaS,PheS,AspS)-N-9-fluorenylmethyloxycarbonyl-alanyl-phenylalanyl-β-(2-trimethylsilylethyl)-α-methyl-aspartate

: 310904-88-2
(AlaS,PheS,AspS)-alanyl-phenylalanyl-β-(2-trimethylsilylethyl)-α-methyl-aspartate

Guidance literature:: With 4-Aminomethylpiperidine; In chloroform;
DOI:10.1007/s007060070065

Reference yield:

: 2916-68-9
2-(Trimethylsilyl)ethanol

: 310904-88-2
(AlaS,PheS,AspS)-alanyl-phenylalanyl-β-(2-trimethylsilylethyl)-α-methyl-aspartate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 72 percent / 1-hydroxybenzotriazole; dicyclohexylcarbodiimide / pyridine; acetonitrile / 2 h / 0 °C

2.1: 100 percent / H₂ / Pd/C / propan-2-ol

3.1: 60 percent / aq. Na₂CO₃ / CHCl₃ / 0.67 h

4.1: 4-(aminomethyl)-piperidine / CHCl₃ / 1.5 h

4.2: 44 percent / aq. Na₂CO₃ / CHCl₃

5.1: 98 percent / 4-(aminomethyl)-piperidine / CHCl₃

With hydrogen; sodium carbonate; benzotriazol-1-ol; 4-Aminomethylpiperidine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In pyridine; chloroform; isopropyl alcohol; acetonitrile;
DOI:10.1007/s007060070065

Reference yield:

: 4668-42-2
(S)-2-benzyloxycarbonylamino-succinic acid 1-methyl ester

: 310904-88-2
(AlaS,PheS,AspS)-alanyl-phenylalanyl-β-(2-trimethylsilylethyl)-α-methyl-aspartate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 72 percent / 1-hydroxybenzotriazole; dicyclohexylcarbodiimide / pyridine; acetonitrile / 2 h / 0 °C

2.1: 100 percent / H₂ / Pd/C / propan-2-ol

3.1: 60 percent / aq. Na₂CO₃ / CHCl₃ / 0.67 h

4.1: 4-(aminomethyl)-piperidine / CHCl₃ / 1.5 h

4.2: 44 percent / aq. Na₂CO₃ / CHCl₃

5.1: 98 percent / 4-(aminomethyl)-piperidine / CHCl₃

With hydrogen; sodium carbonate; benzotriazol-1-ol; 4-Aminomethylpiperidine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In pyridine; chloroform; isopropyl alcohol; acetonitrile;
DOI:10.1007/s007060070065