4-amino-N-(1-((4-chlorophenyl)amino)-6-methylisoquinolin-5-yl)thieno[3,2-d]pyrimidine-7-carboxamide

Base Information

Chemical Name:4-amino-N-(1-((4-chlorophenyl)amino)-6-methylisoquinolin-5-yl)thieno[3,2-d]pyrimidine-7-carboxamide
CAS No.:1446111-26-7
Molecular Formula:C₂₃H₁₇ClN₆OS
Molecular Weight:460.947
Hs Code.:

Synonyms:4-amino-N-(1-((4-chlorophenyl)amino)-6-methylisoquinolin-5-yl)thieno[3,2-d]pyrimidine-7-carboxamide

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Chemical Property of 4-amino-N-(1-((4-chlorophenyl)amino)-6-methylisoquinolin-5-yl)thieno[3,2-d]pyrimidine-7-carboxamide

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Technology Process of 4-amino-N-(1-((4-chlorophenyl)amino)-6-methylisoquinolin-5-yl)thieno[3,2-d]pyrimidine-7-carboxamide

There total 14 articles about 4-amino-N-(1-((4-chlorophenyl)amino)-6-methylisoquinolin-5-yl)thieno[3,2-d]pyrimidine-7-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 1093101-72-4
N¹-(4-chlorophenyl)-6-methylisoquinoline-1,5-diamine

: 1318242-98-6
4-amino-thieno[3,2-d]pyrimidine-7-carboxylic acid

: 1446111-26-7
4-amino-N-(1-((4-chlorophenyl)amino)-6-methylisoquinolin-5-yl)thieno[3,2-d]pyrimidine-7-carboxamide

Guidance literature:: 4-amino-thieno[3,2-d]pyrimidine-7-carboxylic acid; With diethyl chlorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 ℃; for 0.166667h;

N¹-(4-chlorophenyl)-6-methylisoquinoline-1,5-diamine; In N,N-dimethyl-formamide;

Reference yield:

: 31169-27-4
7-bromo-4-chlorothieno[3,2-d]pyrimidine

: 1446111-26-7
4-amino-N-(1-((4-chlorophenyl)amino)-6-methylisoquinolin-5-yl)thieno[3,2-d]pyrimidine-7-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: ammonia / isopropyl alcohol / 7 h / 95 - 100 °C / Sealed tube

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / 1,4-dioxane / Reflux

3.1: ozone / chloroform; methanol / -78 °C / Inert atmosphere

3.2: 20 °C / Inert atmosphere

4.1: sodium dihydrogenphosphate dihydrate; sodium chlorite / water; acetone; dimethyl sulfoxide / 0 - 3 °C

5.1: diethyl chlorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.17 h / 0 °C

With sodium chlorite; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium dihydrogenphosphate dihydrate; ammonia; diethyl chlorophosphate; ozone; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol; chloroform; water; dimethyl sulfoxide; N,N-dimethyl-formamide; isopropyl alcohol; acetone;

Reference yield:

: 1318133-32-2
7-bromothieno[3,2-d]pyrimidine-4-amine

: 1446111-26-7
4-amino-N-(1-((4-chlorophenyl)amino)-6-methylisoquinolin-5-yl)thieno[3,2-d]pyrimidine-7-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / 1,4-dioxane / Reflux

2.1: ozone / chloroform; methanol / -78 °C / Inert atmosphere

2.2: 20 °C / Inert atmosphere

3.1: sodium dihydrogenphosphate dihydrate; sodium chlorite / water; acetone; dimethyl sulfoxide / 0 - 3 °C

4.1: diethyl chlorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.17 h / 0 °C

With sodium chlorite; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium dihydrogenphosphate dihydrate; diethyl chlorophosphate; ozone; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol; chloroform; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone;