N-(-p-(2,3,6,7-tetrahydro-11-oxo-1H,5H,11H-benzopyrano<6,7,8-i,j>quinolizin-10-yl)phenyl)maleamic acid

Base Information

• Chemical Name: N-(-p-(2,3,6,7-tetrahydro-11-oxo-1H,5H,11H-benzopyrano<6,7,8-i,j>quinolizin-10-yl)phenyl)maleamic acid
• CAS No.: 129667-44-3
• Molecular Formula: C₂₅H₂₂N₂O₅
• Molecular Weight: 430.46

Synonyms:N-(-p-(2,3,6,7-tetrahydro-11-oxo-1H,5H,11H-benzopyrano<6,7,8-i,j>quinolizin-10-yl)phenyl)maleamic acid

Chemical Property of N-(-p-(2,3,6,7-tetrahydro-11-oxo-1H,5H,11H-benzopyrano<6,7,8-i,j>quinolizin-10-yl)phenyl)maleamic acid

Chemical Property:

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Technology Process of N-(-p-(2,3,6,7-tetrahydro-11-oxo-1H,5H,11H-benzopyrano<6,7,8-i,j>quinolizin-10-yl)phenyl)maleamic acid

There total 4 articles about N-(-p-(2,3,6,7-tetrahydro-11-oxo-1H,5H,11H-benzopyrano<6,7,8-i,j>quinolizin-10-yl)phenyl)maleamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

maleic anhydride (108-31-6) + 10-(4-aminophenyl)-2,3,6,7-tetrahydro-11-oxo-1H,5H,11H-benzopyrano<6,7,8-i,j>quinolizine (129667-43-2) → N-(-p-(2,3,6,7-tetrahydro-11-oxo-1H,5H,11H-benzopyrano<6,7,8-i,j>quinolizin-10-yl)phenyl)maleamic acid (129667-44-3)

Guidance literature:

In tetrahydrofuran; at 10 - 12 ℃; for 4h;

Reference yield:

ETHYL 4-NITROPHENYLACETATE (5445-26-1) → N-(-p-(2,3,6,7-tetrahydro-11-oxo-1H,5H,11H-benzopyrano<6,7,8-i,j>quinolizin-10-yl)phenyl)maleamic acid (129667-44-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 86 percent / acetic acid, piperidine / butan-1-ol / 43 h / Heating

2: 93 percent / SnCl₂*2H₂O, HCl / 84 h

3: 87 percent / tetrahydrofuran / 4 h / 10 - 12 °C

With piperidine; hydrogenchloride; acetic acid; tin(ll) chloride; In tetrahydrofuran; butan-1-ol;

Reference yield:

9-formyl-8-hydroxyjulolidine (63149-33-7) → N-(-p-(2,3,6,7-tetrahydro-11-oxo-1H,5H,11H-benzopyrano<6,7,8-i,j>quinolizin-10-yl)phenyl)maleamic acid (129667-44-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 86 percent / acetic acid, piperidine / butan-1-ol / 43 h / Heating

2: 93 percent / SnCl₂*2H₂O, HCl / 84 h

3: 87 percent / tetrahydrofuran / 4 h / 10 - 12 °C

With piperidine; hydrogenchloride; acetic acid; tin(ll) chloride; In tetrahydrofuran; butan-1-ol;

upstream raw materials:

maleic anhydride

10-(4-aminophenyl)-2,3,6,7-tetrahydro-11-oxo-1H,5H,11H-benzopyrano<6,7,8-i,j>quinolizine

ETHYL 4-NITROPHENYLACETATE

9-formyl-8-hydroxyjulolidine

Downstream raw materials:

N-(-p-(2,3,6,7-tetrahydro-11-oxo-1H,5H,11H-benzopyrano<6,7,8-i,j>quinolizin-10-yl)phenyl)maleimide

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