2-[2-(3-tert-Butoxycarbonylamino-4-hydroxy-butyl)-phenylamino]-3-methyl-butyric acid methyl ester

Base Information

Chemical Name:2-[2-(3-tert-Butoxycarbonylamino-4-hydroxy-butyl)-phenylamino]-3-methyl-butyric acid methyl ester
CAS No.:168965-67-1
Molecular Formula:C₂₁H₃₄N₂O₅
Molecular Weight:394.511
Hs Code.:

Synonyms:2-[2-(3-tert-Butoxycarbonylamino-4-hydroxy-butyl)-phenylamino]-3-methyl-butyric acid methyl ester

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Chemical Property of 2-[2-(3-tert-Butoxycarbonylamino-4-hydroxy-butyl)-phenylamino]-3-methyl-butyric acid methyl ester

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Technology Process of 2-[2-(3-tert-Butoxycarbonylamino-4-hydroxy-butyl)-phenylamino]-3-methyl-butyric acid methyl ester

There total 7 articles about 2-[2-(3-tert-Butoxycarbonylamino-4-hydroxy-butyl)-phenylamino]-3-methyl-butyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 16793-89-8
(2-bromoethyl)-2-nitrobenzene

: 168965-67-1
2-[2-(3-tert-Butoxycarbonylamino-4-hydroxy-butyl)-phenylamino]-3-methyl-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 81 percent / NaH / dimethylformamide / 20 h / Ambient temperature

2: HCl, AcOH / 9 h / Heating

3: SOCl₂ / 6 h / Ambient temperature

4: CH₂Cl₂ / 36 h / Ambient temperature

5: 63 percent / LiBH₄ / tetrahydrofuran / 1.) 0 deg C, 1 h, 2.) RT, 48 h

6: 98 percent / H₂ / 10percent Pd/C / ethanol / 3 h / 760 Torr / Ambient temperature

7: 2.) NaBH₃CN, 3.) H₂ / 3.) Pd/C

With hydrogenchloride; lithium borohydride; thionyl chloride; hydrogen; sodium hydride; sodium cyanoborohydride; acetic acid; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja953578v

Reference yield:

: 105260-07-9
2-amino-4-(2-nitrophenyl)butyric acid

: 168965-67-1
2-[2-(3-tert-Butoxycarbonylamino-4-hydroxy-butyl)-phenylamino]-3-methyl-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: SOCl₂ / 6 h / Ambient temperature

2: CH₂Cl₂ / 36 h / Ambient temperature

3: 63 percent / LiBH₄ / tetrahydrofuran / 1.) 0 deg C, 1 h, 2.) RT, 48 h

4: 98 percent / H₂ / 10percent Pd/C / ethanol / 3 h / 760 Torr / Ambient temperature

5: 2.) NaBH₃CN, 3.) H₂ / 3.) Pd/C

With lithium borohydride; thionyl chloride; hydrogen; sodium cyanoborohydride; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/ja953578v

Reference yield:

: 86499-33-4
ethyl 2-amino-4-(2-nitrophenyl)butyrate

: 168965-67-1
2-[2-(3-tert-Butoxycarbonylamino-4-hydroxy-butyl)-phenylamino]-3-methyl-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: CH₂Cl₂ / 36 h / Ambient temperature

2: 63 percent / LiBH₄ / tetrahydrofuran / 1.) 0 deg C, 1 h, 2.) RT, 48 h

3: 98 percent / H₂ / 10percent Pd/C / ethanol / 3 h / 760 Torr / Ambient temperature

4: 2.) NaBH₃CN, 3.) H₂ / 3.) Pd/C

With lithium borohydride; hydrogen; sodium cyanoborohydride; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/ja953578v