Technology Process of 4-dimethylamino-1-[3-(1H-indol-3-yl)propyl]-4-phenylcyclohexanol
There total 6 articles about 4-dimethylamino-1-[3-(1H-indol-3-yl)propyl]-4-phenylcyclohexanol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
tetrabutyl ammonium fluoride; water;
In
tetrahydrofuran;
at 50 ℃;
Reflux;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: tert.-butyl lithium / diethyl ether; pentane / -75 - -70 °C
2: [1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene](3-chloropyridyl)palladium(ll) dichloride; sodium carbonate / N,N-dimethyl-formamide / 100 °C
3: tetrabutyl ammonium fluoride / tetrahydrofuran / 50 °C
With
[1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene](3-chloropyridyl)palladium(ll) dichloride; tetrabutyl ammonium fluoride; tert.-butyl lithium; sodium carbonate;
In
tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide; pentane;
2: |Larock Annulation;
DOI:10.1021/ml500117c
- Guidance literature:
-
Multi-step reaction with 4 steps
1: triphenylphospine diiodide; 1H-imidazole / acetonitrile
2: tert.-butyl lithium / diethyl ether; pentane / -75 - -70 °C
3: [1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene](3-chloropyridyl)palladium(ll) dichloride; sodium carbonate / N,N-dimethyl-formamide / 100 °C
4: tetrabutyl ammonium fluoride / tetrahydrofuran / 50 °C
With
1H-imidazole; [1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene](3-chloropyridyl)palladium(ll) dichloride; tetrabutyl ammonium fluoride; tert.-butyl lithium; sodium carbonate; triphenylphospine diiodide;
In
tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide; acetonitrile; pentane;
3: |Larock Annulation;
DOI:10.1021/ml500117c