4-dimethylamino-4-phenyl-1-[3-(2-triethylsilanyl-1H-indol-3-yl)propyl]cyclohexanol

Base Information

Chemical Name:4-dimethylamino-4-phenyl-1-[3-(2-triethylsilanyl-1H-indol-3-yl)propyl]cyclohexanol
CAS No.:1189758-86-8
Molecular Formula:C₃₁H₄₆N₂OSi
Molecular Weight:490.805
Hs Code.:

Synonyms:4-dimethylamino-4-phenyl-1-[3-(2-triethylsilanyl-1H-indol-3-yl)propyl]cyclohexanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-dimethylamino-4-phenyl-1-[3-(2-triethylsilanyl-1H-indol-3-yl)propyl]cyclohexanol

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Technology Process of 4-dimethylamino-4-phenyl-1-[3-(2-triethylsilanyl-1H-indol-3-yl)propyl]cyclohexanol

There total 3 articles about 4-dimethylamino-4-phenyl-1-[3-(2-triethylsilanyl-1H-indol-3-yl)propyl]cyclohexanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1189758-84-6
4-dimethylamino-4-phenyl-1-(5-triethylsilanyl-pent-4-inyl)cyclohexanol

: 615-43-0
2-iodophenylamine

: 1189758-86-8
4-dimethylamino-4-phenyl-1-[3-(2-triethylsilanyl-1H-indol-3-yl)propyl]cyclohexanol

Guidance literature:: With sodium carbonate; [1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene](3-chloropyridyl)palladium(ll) dichloride; In N,N-dimethyl-formamide; at 100 ℃; for 18h; Inert atmosphere;

Reference yield:

: 65619-20-7
4-dimethylamino-4-phenylcyclohexanone

: 1189758-86-8
4-dimethylamino-4-phenyl-1-[3-(2-triethylsilanyl-1H-indol-3-yl)propyl]cyclohexanol

Guidance literature:: Multi-step reaction with 2 steps

1: tert.-butyl lithium / diethyl ether; pentane / -75 - -70 °C

2: [1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene](3-chloropyridyl)palladium(ll) dichloride; sodium carbonate / N,N-dimethyl-formamide / 100 °C

With [1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene](3-chloropyridyl)palladium(ll) dichloride; tert.-butyl lithium; sodium carbonate; In diethyl ether; N,N-dimethyl-formamide; pentane; 2: |Larock Annulation;
DOI:10.1021/ml500117c

Reference yield:

: 4746-97-8
cyclohexanedione monoethylene ketal

: 1189758-86-8
4-dimethylamino-4-phenyl-1-[3-(2-triethylsilanyl-1H-indol-3-yl)propyl]cyclohexanol

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogenchloride / water; methanol / 0 - 20 °C

2.1: tetrahydrofuran / 0 - 20 °C

2.2: 0 - 20 °C

3.1: water; hydrogenchloride / diethyl ether

4.1: tert.-butyl lithium / diethyl ether; pentane / -75 - -70 °C

5.1: [1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene](3-chloropyridyl)palladium(ll) dichloride; sodium carbonate / N,N-dimethyl-formamide / 100 °C

With hydrogenchloride; [1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene](3-chloropyridyl)palladium(ll) dichloride; water; tert.-butyl lithium; sodium carbonate; In tetrahydrofuran; methanol; diethyl ether; water; N,N-dimethyl-formamide; pentane; 5.1: |Larock Annulation;
DOI:10.1021/ml500117c