(S)-3-Amino-2-(2,3-bis-benzyloxy-benzoylamino)-propionic acid 4-bromo-benzyl ester; hydrochloride

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Chemical Name:(S)-3-Amino-2-(2,3-bis-benzyloxy-benzoylamino)-propionic acid 4-bromo-benzyl ester; hydrochloride
CAS No.:78089-16-4
Molecular Formula:C₃₁H₂₉BrN₂O₅*ClH
Molecular Weight:625.947
Hs Code.:

Synonyms:(S)-3-Amino-2-(2,3-bis-benzyloxy-benzoylamino)-propionic acid 4-bromo-benzyl ester; hydrochloride

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Chemical Property of (S)-3-Amino-2-(2,3-bis-benzyloxy-benzoylamino)-propionic acid 4-bromo-benzyl ester; hydrochloride

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Technology Process of (S)-3-Amino-2-(2,3-bis-benzyloxy-benzoylamino)-propionic acid 4-bromo-benzyl ester; hydrochloride

There total 7 articles about (S)-3-Amino-2-(2,3-bis-benzyloxy-benzoylamino)-propionic acid 4-bromo-benzyl ester; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 78089-15-3
(S)-2-(2,3-Bis-benzyloxy-benzoylamino)-3-tert-butoxycarbonylamino-propionic acid 4-bromo-benzyl ester

: 78089-16-4
(S)-3-Amino-2-(2,3-bis-benzyloxy-benzoylamino)-propionic acid 4-bromo-benzyl ester; hydrochloride

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; for 1.5h; Ambient temperature;
DOI:10.1021/jo00331a001

Reference yield:

: 5779-91-9
2,3-bis(benzyloxy)benzaldehyde

: 78089-16-4
(S)-3-Amino-2-(2,3-bis-benzyloxy-benzoylamino)-propionic acid 4-bromo-benzyl ester; hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: 94 percent / H₂NSO₃H, NaClO₂ / acetone; H₂O / 1 h / Ambient temperature

2: 94 percent / oxalyl chloride / DMF / benzene / 0.5 h / 5 °C

3: 1.) Na, NH₃ liq, 2.) NaHCO₃ / 1.) 1h, reflux, 2.) 1h, r.t.

4: 98 percent / CsCO₃ / methanol; H₂O; dimethylformamide / 15 h / Ambient temperature

5: 84 percent / HCl / tetrahydrofuran / 1.5 h / Ambient temperature

With hydrogenchloride; sodium chlorite; oxalyl dichloride; aminosulfonic acid; ammonia; sodium; sodium hydrogencarbonate; DMF; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; acetone; benzene;
DOI:10.1021/jo00331a001

Reference yield:

: 24677-78-9
2,3-dihydroxybenzaldehyde

: 78089-16-4
(S)-3-Amino-2-(2,3-bis-benzyloxy-benzoylamino)-propionic acid 4-bromo-benzyl ester; hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1: K₂CO₃ / ethanol / 18 h / Heating

2: 94 percent / H₂NSO₃H, NaClO₂ / acetone; H₂O / 1 h / Ambient temperature

3: 94 percent / oxalyl chloride / DMF / benzene / 0.5 h / 5 °C

4: 1.) Na, NH₃ liq, 2.) NaHCO₃ / 1.) 1h, reflux, 2.) 1h, r.t.

5: 98 percent / CsCO₃ / methanol; H₂O; dimethylformamide / 15 h / Ambient temperature

6: 84 percent / HCl / tetrahydrofuran / 1.5 h / Ambient temperature

With hydrogenchloride; sodium chlorite; oxalyl dichloride; aminosulfonic acid; ammonia; sodium; sodium hydrogencarbonate; potassium carbonate; DMF; In tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide; acetone; benzene;
DOI:10.1021/jo00331a001