2-(3-METHOXY-4-BROMOPHENYL)ETHYLAMINE

Base Information

• Chemical Name: 2-(3-METHOXY-4-BROMOPHENYL)ETHYLAMINE
• CAS No.: 113081-51-9
• Molecular Formula: C₉H₁₂BrNO
• Molecular Weight: 230.104
• Hs Code.: 2922199090
• Mol file: 113081-51-9.mol

Synonyms:4-Bromo-3-methoxyphenethylamine

Chemical Property of 2-(3-METHOXY-4-BROMOPHENYL)ETHYLAMINE

Chemical Property:

• Boiling Point: 303.2±27.0 °C(Predicted)
• PKA: 9.61±0.10(Predicted)
• PSA: 35.25000
• Density: 1.385±0.06 g/cm3(Predicted)
• LogP: 2.65920

Purity/Quality:

98%Min ^*data from raw suppliers

2-(3-Methoxy-4-bromophenyl)ethylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(3-METHOXY-4-BROMOPHENYL)ETHYLAMINE

There total 7 articles about 2-(3-METHOXY-4-BROMOPHENYL)ETHYLAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

1-bromo-2-methoxy-4-((E)-2-nitro-vinyl)-benzene (1177015-72-3) → 2-(4-bromo-3-methoxy-phenyl)-ethylamine (113081-51-9)

Guidance literature:

1-bromo-2-methoxy-4-((E)-2-nitro-vinyl)-benzene; With methanol; sodium tetrahydroborate; at 0 - 20 ℃; for 1h;

With ammonium chloride; acetic acid; zinc; In water; at 50 ℃; for 1h;

Reference yield:

4-amino-3-methoxybenzaldehyde (90151-40-9) → 2-(4-bromo-3-methoxy-phenyl)-ethylamine (113081-51-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: n-Butyl nitrite; copper(I) bromide / acetonitrile / 12 h / 20 °C

2.1: acetic acid; ammonium acetate / 12 h / 80 °C

3.1: sodium tetrahydroborate; methanol / 1 h / 0 - 20 °C

3.2: 1 h / 50 °C

With methanol; sodium tetrahydroborate; n-Butyl nitrite; ammonium acetate; acetic acid; copper(I) bromide; In acetonitrile;

Reference yield:

1-bromo-2-methoxy-4-(2-nitrovinyl)benzene → 2-(4-bromo-3-methoxy-phenyl)-ethylamine (113081-51-9)

Guidance literature:

1-bromo-2-methoxy-4-(2-nitrovinyl)benzene; With borane-THF; In tetrahydrofuran; at 0 ℃; Inert atmosphere;

With sodium tetrahydroborate; In tetrahydrofuran; at 65 ℃; for 18h; Inert atmosphere;

upstream raw materials:

2-(4-bromo-3-methoxyphenyl)acetonitrile

1-bromo-2-methoxy-4-((E)-2-nitro-vinyl)-benzene

3-methoxy-4-nitrobenzaldehyde

5-formyl-2-nitrophenol

Downstream raw materials:

N-[2-(4-bromo-3-methoxy-phenyl)-ethyl]-formamide

(S)-N-[2-(4-bromo-3-methoxy-phenyl)-ethyl]-2-formylamino-3,3-dimethyl-butyramide

(R)-3-(3-fluorophenyl)-N-(1-hydroxy-3-(1H-indol-3-yl)propan-2-yl)-8-methoxy-9-(pyridin-3-yl)-5,6-dihydropyrrolo[2,1-a]isoquinoline-2-carboxamide

ethyl 9-ethyl-3-(3-fluorophenyl)-8-methoxy-5,6-dihydropyrrolo[2,1-a]isoquinoline-2-carboxylate

Refernces

• 1、 -. "PHARMACEUTICAL COMPOUNDS". Page/Page column 91; 132. . Retrieved 2015/09/23.
• 2、 -. "(DIHYDRO) IMIDAZOISO (5, 1-A) QUINOLINES AS FSH RECEPTOR AGONISTS FOR THE TREATMENT OF FERTILITY DISORDERS". Page/Page column 30-31. . Retrieved 2010/12/26.