3-[2-(4-bromophenylsulfanyl)acetylamino]thiophene-2-carboxylic acid dimethylamide

Base Information

Chemical Name:3-[2-(4-bromophenylsulfanyl)acetylamino]thiophene-2-carboxylic acid dimethylamide
CAS No.:1075120-41-0
Molecular Formula:C₁₅H₁₅BrN₂O₂S₂
Molecular Weight:399.332
Hs Code.:

Synonyms:3-[2-(4-bromophenylsulfanyl)acetylamino]thiophene-2-carboxylic acid dimethylamide

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Chemical Property of 3-[2-(4-bromophenylsulfanyl)acetylamino]thiophene-2-carboxylic acid dimethylamide

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Technology Process of 3-[2-(4-bromophenylsulfanyl)acetylamino]thiophene-2-carboxylic acid dimethylamide

There total 4 articles about 3-[2-(4-bromophenylsulfanyl)acetylamino]thiophene-2-carboxylic acid dimethylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1075120-32-9
3-[2-(4-bromophenylsulfanyl)acetylamino]thiophene-2-carboxylic acid

: 124-40-3
dimethyl amine

: 1075120-41-0
3-[2-(4-bromophenylsulfanyl)acetylamino]thiophene-2-carboxylic acid dimethylamide

Guidance literature:: 3-[2-(4-bromophenylsulfanyl)acetylamino]thiophene-2-carboxylic acid; With dmap; 2,2'-dipyridyl carbonate; In tetrahydrofuran; at 20 ℃; for 3h; Inert atmosphere;

dimethyl amine; In tetrahydrofuran; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1016/j.bmcl.2013.07.018

Reference yield:

: 22288-78-4
Methyl 3-aminothiophene-2-carboxylate

: 1075120-41-0
3-[2-(4-bromophenylsulfanyl)acetylamino]thiophene-2-carboxylic acid dimethylamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / tetrahydrofuran / 20 °C

2.1: triethylamine / tetrahydrofuran / 20 °C

3.1: sodium hydroxide / tetrahydrofuran / Reflux

4.1: 2,2'-dipyridyl carbonate; dmap / tetrahydrofuran / 3 h / 20 °C / Inert atmosphere

4.2: 2 h / 20 °C / Inert atmosphere

With dmap; 2,2'-dipyridyl carbonate; triethylamine; sodium hydroxide; In tetrahydrofuran;
DOI:10.1016/j.bmcl.2013.07.018

Reference yield:

: 477869-14-0
C₁₄H₁₂BrNO₃S₂

: 1075120-41-0
3-[2-(4-bromophenylsulfanyl)acetylamino]thiophene-2-carboxylic acid dimethylamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide / tetrahydrofuran / Reflux

2.1: 2,2'-dipyridyl carbonate; dmap / tetrahydrofuran / 3 h / 20 °C / Inert atmosphere

2.2: 2 h / 20 °C / Inert atmosphere

With dmap; 2,2'-dipyridyl carbonate; sodium hydroxide; In tetrahydrofuran;
DOI:10.1016/j.bmcl.2013.07.018