*,R^*)>-3-<2-(2,2-dimethyl-1-oxopropoxy)-1-oxo-6-<<(phenylmethoxy)carbonyl>amino>hexyl>-4-oxazolidinecarboxylic acid methyl ester

Base Information

• Chemical Name: *,R^*)>-3-<2-(2,2-dimethyl-1-oxopropoxy)-1-oxo-6-<<(phenylmethoxy)carbonyl>amino>hexyl>-4-oxazolidinecarboxylic acid methyl ester
• CAS No.: 126111-27-1
• Molecular Formula: C₂₄H₃₄N₂O₈
• Molecular Weight: 478.543

Synonyms:*,R^*)>-3-<2-(2,2-dimethyl-1-oxopropoxy)-1-oxo-6-<<(phenylmethoxy)carbonyl>amino>hexyl>-4-oxazolidinecarboxylic acid methyl ester

Chemical Property of *,R^*)>-3-<2-(2,2-dimethyl-1-oxopropoxy)-1-oxo-6-<<(phenylmethoxy)carbonyl>amino>hexyl>-4-oxazolidinecarboxylic acid methyl ester

Chemical Property:

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Technology Process of *,R^*)>-3-<2-(2,2-dimethyl-1-oxopropoxy)-1-oxo-6-<<(phenylmethoxy)carbonyl>amino>hexyl>-4-oxazolidinecarboxylic acid methyl ester

There total 3 articles about *,R^*)>-3-<2-(2,2-dimethyl-1-oxopropoxy)-1-oxo-6-<<(phenylmethoxy)carbonyl>amino>hexyl>-4-oxazolidinecarboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-3-<(phenylmethoxy)carbonyl>-4-oxazolidinecarboxylic acid methyl ester (126111-22-6) → *,R*)>-3-<2-(2,2-dimethyl-1-oxopropoxy)-1-oxo-6-<<(phenylmethoxy)carbonyl>amino>hexyl>-4-oxazolidinecarboxylic acid methyl ester (126111-27-1)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N, H₂ / 20percent Pd(OH)2/C / ethyl acetate / 1.5 h

2: triethylamine, 4-(dimethylamino)pyridine / tetrahydrofuran / 16 h / Ambient temperature

With dmap; hydrogen; triethylamine; palladium dihydroxide; In tetrahydrofuran; ethyl acetate;

DOI:10.1021/jm00167a028

Reference yield:

pivaloyl chloride (3282-30-2) → *,R*)>-3-<2-(2,2-dimethyl-1-oxopropoxy)-1-oxo-6-<<(phenylmethoxy)carbonyl>amino>hexyl>-4-oxazolidinecarboxylic acid methyl ester (126111-27-1)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N, 4-(dimethylamino)pyridine / tetrahydrofuran / 1.5 h / 0 °C

2: triethylamine, 4-(dimethylamino)pyridine / tetrahydrofuran / 16 h / Ambient temperature

With dmap; triethylamine; In tetrahydrofuran;

DOI:10.1021/jm00167a028

Reference yield:

(S)-Oxazolidine-4-carboxylic acid methyl ester + 2,2-Dimethyl-propionic acid (S)-5-benzyloxycarbonylamino-1-(2,2-dimethyl-propionyloxycarbonyl)-pentyl ester → *,R*)>-3-<2-(2,2-dimethyl-1-oxopropoxy)-1-oxo-6-<<(phenylmethoxy)carbonyl>amino>hexyl>-4-oxazolidinecarboxylic acid methyl ester (126111-27-1)

Guidance literature:

With dmap; triethylamine; In tetrahydrofuran; for 16h; Yield given; Ambient temperature;

DOI:10.1021/jm00167a028

upstream raw materials:

(S)-3-<(phenylmethoxy)carbonyl>-4-oxazolidinecarboxylic acid methyl ester

pivaloyl chloride

Downstream raw materials:

*,R^*)>-3-<2-hydroxy-1-oxo-6-<<(phenylmethoxy)carbonyl>amino>hexyl>-4-oxazolidinecarboxylic acid methyl ester

(S)-3-{(S)-6-Amino-2-[hydroxy-(4-phenyl-butyl)-phosphinoyloxy]-hexanoyl}-oxazolidine-4-carboxylic acid

(S)-3-{(S)-6-Benzyloxycarbonylamino-2-[hydroxy-(4-phenyl-butyl)-phosphinoyloxy]-hexanoyl}-oxazolidine-4-carboxylic acid methyl ester

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