4-amino-1-benzyl-6-trifluoromethyl-1,3-dihydroimidazo[4,5-c]pyridin-2-one

Base Information

Chemical Name:4-amino-1-benzyl-6-trifluoromethyl-1,3-dihydroimidazo[4,5-c]pyridin-2-one
CAS No.:947142-81-6
Molecular Formula:C₁₄H₁₁F₃N₄O
Molecular Weight:308.263
Hs Code.:

Synonyms:4-amino-1-benzyl-6-trifluoromethyl-1,3-dihydroimidazo[4,5-c]pyridin-2-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-amino-1-benzyl-6-trifluoromethyl-1,3-dihydroimidazo[4,5-c]pyridin-2-one

Chemical Property:

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MSDS Files:: SDS file from LookChem

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Technology Process of 4-amino-1-benzyl-6-trifluoromethyl-1,3-dihydroimidazo[4,5-c]pyridin-2-one

There total 15 articles about 4-amino-1-benzyl-6-trifluoromethyl-1,3-dihydroimidazo[4,5-c]pyridin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 947143-87-5
benzyl-(2,3-diamino-6-trifluoromethylpyridin-4-yl)carbamic acid ethyl ester

: 947142-81-6
4-amino-1-benzyl-6-trifluoromethyl-1,3-dihydroimidazo[4,5-c]pyridin-2-one

Guidance literature:: With acetic acid; at 100 ℃; Large scale reaction;
DOI:10.1021/op200021a

Reference yield: 79.0%

: 947143-86-4
1-Benzyl-4-benzylamino-6-trifluoromethyl-1,3-dihydro-imidazo[4,5-c]pyridine-2-one

: 947142-81-6
4-amino-1-benzyl-6-trifluoromethyl-1,3-dihydroimidazo[4,5-c]pyridin-2-one

Guidance literature:: With sulfuric acid; Large scale reaction;
DOI:10.1021/op200021a

Reference yield:

: 947144-53-8
4-chloro-3-nitro-6-trifluoromethyl-1H-pyridin-2-one

: 947142-81-6
4-amino-1-benzyl-6-trifluoromethyl-1,3-dihydroimidazo[4,5-c]pyridin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: tetrahydrofuran / 22 h / Reflux; Large scale reaction

2.1: P,P-dichlorophenylphosphine oxide / dichloromethane / 22 h / 95 °C / Inert atmosphere; Large scale reaction

3.1: potassium tert-butylate / tetrahydrofuran / 1.5 h / -10 - -8 °C / Inert atmosphere; Large scale reaction

3.2: 1.5 h / -10 - -7 °C

4.1: ammonia / tetrahydrofuran / 41 h / 45 - 50 °C / Large scale reaction

5.1: 10% Pd(OH)₂ on C; hydrogen / ethanol / 3 h / 20 °C / 5925.59 Torr / Large scale reaction

6.1: acetic acid / 100 °C / Large scale reaction

With P,P-dichlorophenylphosphine oxide; 10% Pd(OH)₂ on C; potassium tert-butylate; ammonia; hydrogen; acetic acid; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/op200021a