benzyl-(2,3-diamino-6-trifluoromethylpyridin-4-yl)carbamic acid ethyl ester

Base Information

• Chemical Name: benzyl-(2,3-diamino-6-trifluoromethylpyridin-4-yl)carbamic acid ethyl ester
• CAS No.: 947143-87-5
• Molecular Formula: C₁₆H₁₇F₃N₄O₂
• Molecular Weight: 354.332

Synonyms:benzyl-(2,3-diamino-6-trifluoromethylpyridin-4-yl)carbamic acid ethyl ester

Chemical Property of benzyl-(2,3-diamino-6-trifluoromethylpyridin-4-yl)carbamic acid ethyl ester

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Technology Process of benzyl-(2,3-diamino-6-trifluoromethylpyridin-4-yl)carbamic acid ethyl ester

There total 8 articles about benzyl-(2,3-diamino-6-trifluoromethylpyridin-4-yl)carbamic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

(2-amino-3-nitro-6-trifluoromethylpyridin-4-yl)benzylcarbamic acid ethyl ester (947144-34-5) → benzyl-(2,3-diamino-6-trifluoromethylpyridin-4-yl)carbamic acid ethyl ester (947143-87-5) + C6H7F3N4

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethanol; at 40 ℃; for 3h; under 2585.81 Torr;

DOI:10.1021/op200021a

Reference yield: 60.0%

(2-amino-3-nitro-6-trifluoromethylpyridin-4-yl)benzylcarbamic acid ethyl ester (947144-34-5) → benzyl-(2,3-diamino-6-trifluoromethylpyridin-4-yl)carbamic acid ethyl ester (947143-87-5)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In ethanol; at 40 ℃; for 1h; under 2068.65 Torr;

Reference yield:

benzyl-(2-chloro-3-nitro-6-trifluoromethylpyridin-4-yl)amine (947144-18-5) → benzyl-(2,3-diamino-6-trifluoromethylpyridin-4-yl)carbamic acid ethyl ester (947143-87-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium tert-butylate / tetrahydrofuran / 1.5 h / -10 - -8 °C / Inert atmosphere; Large scale reaction

1.2: 1.5 h / -10 - -7 °C

2.1: ammonia / tetrahydrofuran / 41 h / 45 - 50 °C / Large scale reaction

3.1: 10% Pd(OH)₂ on C; hydrogen / ethanol / 3 h / 20 °C / 5925.59 Torr / Large scale reaction

With 10% Pd(OH)₂ on C; potassium tert-butylate; ammonia; hydrogen; In tetrahydrofuran; ethanol;

DOI:10.1021/op200021a

upstream raw materials:

(2-amino-3-nitro-6-trifluoromethylpyridin-4-yl)benzylcarbamic acid ethyl ester

benzyl-(2-chloro-3-nitro-6-trifluoromethylpyridin-4-yl)amine

4-hydroxy-2-oxo-6-trifluoromethyl-1,2-dihydropyridine-3-carboxylic acid ethyl ester

4-hydroxy-3-nitro-6-trifluoromethyl-1H-pyridin-2-one

Downstream raw materials:

4-amino-1-benzyl-6-trifluoromethyl-1,3-dihydroimidazo[4,5-c]pyridin-2-one

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