benzyl-(2-chloro-3-nitro-6-trifluoromethylpyridin-4-yl)amine

Base Information

• Chemical Name: benzyl-(2-chloro-3-nitro-6-trifluoromethylpyridin-4-yl)amine
• CAS No.: 947144-18-5
• Molecular Formula: C₁₃H₉ClF₃N₃O₂
• Molecular Weight: 331.682
• Mol file: 947144-18-5.mol

Synonyms:benzyl-(2-chloro-3-nitro-6-trifluoromethylpyridin-4-yl)amine

Chemical Property of benzyl-(2-chloro-3-nitro-6-trifluoromethylpyridin-4-yl)amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzyl-(2-chloro-3-nitro-6-trifluoromethylpyridin-4-yl)amine

There total 5 articles about benzyl-(2-chloro-3-nitro-6-trifluoromethylpyridin-4-yl)amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

4-(benzylamino)-3-nitro-6-(trifluoromethyl)pyridin-2-ol (947144-38-9) → benzyl-(2-chloro-3-nitro-6-trifluoromethylpyridin-4-yl)amine (947144-18-5)

Guidance literature:

4-(benzylamino)-3-nitro-6-(trifluoromethyl)pyridin-2-ol; With P,P-dichlorophenylphosphine oxide; at 100 ℃;

With sodium hydrogencarbonate; In water; ethyl acetate;

Reference yield: 77.0%

4-benzylamino-3-nitro-6-trifluoromethyl-1H-pyridin-2-one (947144-38-9) → benzyl-(2-chloro-3-nitro-6-trifluoromethylpyridin-4-yl)amine (947144-18-5)

Guidance literature:

With P,P-dichlorophenylphosphine oxide; In dichloromethane; at 95 ℃; for 22h; Inert atmosphere; Large scale reaction;

DOI:10.1021/op200021a

Reference yield:

4-hydroxy-2-oxo-6-trifluoromethyl-1,2-dihydropyridine-3-carboxylic acid ethyl ester (947144-28-7) → benzyl-(2-chloro-3-nitro-6-trifluoromethylpyridin-4-yl)amine (947144-18-5)

Guidance literature:

Multi-step reaction with 5 steps

1: hydrogenchloride / water / Reflux

2: sulfuric acid; nitric acid / 5.5 h / 20 - 50 °C

3: P,P-dichlorophenylphosphine oxide / dichloromethane / 15 h / 95 °C / Inert atmosphere; Large scale reaction

4: tetrahydrofuran / 22 h / Reflux; Large scale reaction

5: P,P-dichlorophenylphosphine oxide / dichloromethane / 22 h / 95 °C / Inert atmosphere; Large scale reaction

With P,P-dichlorophenylphosphine oxide; hydrogenchloride; sulfuric acid; nitric acid; In tetrahydrofuran; dichloromethane; water;

DOI:10.1021/op200021a

upstream raw materials:

4-(benzylamino)-3-nitro-6-(trifluoromethyl)pyridin-2-ol

4-hydroxy-2-oxo-6-trifluoromethyl-1,2-dihydropyridine-3-carboxylic acid ethyl ester

4-hydroxy-3-nitro-6-trifluoromethyl-1H-pyridin-2-one

4-chloro-3-nitro-6-trifluoromethyl-1H-pyridin-2-one

Downstream raw materials:

benzyl-(2,3-diamino-6-trifluoromethylpyridin-4-yl)carbamic acid ethyl ester

4-amino-1-benzyl-6-trifluoromethyl-1,3-dihydroimidazo[4,5-c]pyridin-2-one

1-benzyl-4-chloro-6-trifluoromethyl-1,3-dihydro-imidazo[4,5-c]pyridine-2-one

1-Benzyl-4-benzylamino-6-trifluoromethyl-1,3-dihydro-imidazo[4,5-c]pyridine-2-one