Technology Process of tert-butyl N-(7-ethoxy-4-(3,4,5-trimethoxybenzyl)isoquinolin-8-yl)sulfamoylcarbamate
There total 6 articles about tert-butyl N-(7-ethoxy-4-(3,4,5-trimethoxybenzyl)isoquinolin-8-yl)sulfamoylcarbamate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
isocyanate de chlorosulfonyle; tert-butyl alcohol;
at 0 - 20 ℃;
for 2h;
7-ethoxy-4-(3,4,5-trimethoxybenzyl)isoquinolin-8-amine;
at 20 ℃;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: toluene / 4 h / 150 °C / Inert atmosphere
2.1: ethanol; sodium tetrahydroborate / 1 h / 100 °C / Inert atmosphere
3.1: hydrogenchloride / ethanol / 0.33 h / 100 °C / Microwave irradiation
3.2: pH 7
4.1: triethylamine / N,N-dimethyl-formamide / 0.33 h / 20 °C
5.1: caesium carbonate; Benzophenone imine / 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium(0) / toluene / 5 h / 150 °C / Microwave irradiation
6.1: 2 h / 0 - 20 °C
6.2: 20 °C
With
hydrogenchloride; Benzophenone imine; sodium tetrahydroborate; ethanol; caesium carbonate; triethylamine;
tris-(dibenzylideneacetone)dipalladium(0); 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl;
In
ethanol; N,N-dimethyl-formamide; toluene;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: ethanol; sodium tetrahydroborate / 1 h / 100 °C / Inert atmosphere
2.1: hydrogenchloride / ethanol / 0.33 h / 100 °C / Microwave irradiation
2.2: pH 7
3.1: triethylamine / N,N-dimethyl-formamide / 0.33 h / 20 °C
4.1: caesium carbonate; Benzophenone imine / 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium(0) / toluene / 5 h / 150 °C / Microwave irradiation
5.1: 2 h / 0 - 20 °C
5.2: 20 °C
With
hydrogenchloride; Benzophenone imine; sodium tetrahydroborate; ethanol; caesium carbonate; triethylamine;
tris-(dibenzylideneacetone)dipalladium(0); 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl;
In
ethanol; N,N-dimethyl-formamide; toluene;
