tert-butyl 2,2-dimethyl-5-(4-(4-hexylbenzyl)phenethyl)-1,3-dioxan-5-ylcarbamate

Base Information

Chemical Name:tert-butyl 2,2-dimethyl-5-(4-(4-hexylbenzyl)phenethyl)-1,3-dioxan-5-ylcarbamate
CAS No.:1427308-29-9
Molecular Formula:C₃₂H₄₇NO₄
Molecular Weight:509.729
Hs Code.:

Synonyms:tert-butyl 2,2-dimethyl-5-(4-(4-hexylbenzyl)phenethyl)-1,3-dioxan-5-ylcarbamate

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Chemical Property of tert-butyl 2,2-dimethyl-5-(4-(4-hexylbenzyl)phenethyl)-1,3-dioxan-5-ylcarbamate

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Technology Process of tert-butyl 2,2-dimethyl-5-(4-(4-hexylbenzyl)phenethyl)-1,3-dioxan-5-ylcarbamate

There total 4 articles about tert-butyl 2,2-dimethyl-5-(4-(4-hexylbenzyl)phenethyl)-1,3-dioxan-5-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 60982-72-1
4-hexylbenzyl bromide

: 1427308-22-2
tert-butyl 2,2-dimethyl-5-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenethyl)-1,3-dioxan-5-ylcarbamate

: 1427308-29-9
tert-butyl 2,2-dimethyl-5-(4-(4-hexylbenzyl)phenethyl)-1,3-dioxan-5-ylcarbamate

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,4-dioxane; for 12h; Inert atmosphere; Reflux;
DOI:10.1016/j.tet.2013.02.030

Reference yield:

: 364631-73-2
tert-butyl 5-formyl-2,2-dimethyl-1,3-dioxan-5-ylcarbamate

: 1427308-29-9
tert-butyl 2,2-dimethyl-5-(4-(4-hexylbenzyl)phenethyl)-1,3-dioxan-5-ylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / tetrahydrofuran; N,N-dimethyl-formamide / 6 h / Reflux

2: palladium 10% on activated carbon; hydrogen / methanol / 8 h / 20 °C

3: dibenzoyl peroxide; tert.-butylnitrite / acetonitrile / 5 h / 20 °C

4: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 12 h / Inert atmosphere; Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; tert.-butylnitrite; palladium 10% on activated carbon; hydrogen; potassium carbonate; dibenzoyl peroxide; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide; acetonitrile; 4: |Suzuki Coupling;
DOI:10.1016/j.tet.2013.02.030

Reference yield:

: 1427308-40-4
C₁₉H₂₆N₂O₆

: 1427308-29-9
tert-butyl 2,2-dimethyl-5-(4-(4-hexylbenzyl)phenethyl)-1,3-dioxan-5-ylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 8 h / 20 °C

2: dibenzoyl peroxide; tert.-butylnitrite / acetonitrile / 5 h / 20 °C

3: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 12 h / Inert atmosphere; Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; tert.-butylnitrite; palladium 10% on activated carbon; hydrogen; potassium carbonate; dibenzoyl peroxide; In 1,4-dioxane; methanol; acetonitrile; 3: |Suzuki Coupling;
DOI:10.1016/j.tet.2013.02.030