Technology Process of N3-benzoyl-1-(2'-O-benzoyl-β-D-ribopyranosyl)thymine
There total 4 articles about N3-benzoyl-1-(2'-O-benzoyl-β-D-ribopyranosyl)thymine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
1-(β-D-ribopyranosyl)thymine;
With
p-Anisaldehyde dimethyl acetal; toluene-4-sulfonic acid;
In
N,N-dimethyl-formamide;
at 55 ℃;
under 24.752 Torr;
benzoyl chloride;
With
dmap;
In
pyridine;
at 20 ℃;
for 16h;
With
trifluoroacetic acid;
In
tetrahydrofuran; methanol;
at 20 ℃;
for 1h;
DOI:10.1002/hlca.200390349
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 90 percent / bis(trimethylsilyl)acetamide; TMS-OTf / acetonitrile / 3 h / 60 °C
2.1: 82 percent / NH3 / methanol / 18 h / 20 °C
3.1: TsOH*H2O; p-methoxybenzaldehyde dimethyl acetal / dimethylformamide / 55 °C / 24.75 Torr
3.2: DMAP / pyridine / 16 h / 20 °C
3.3: 8.1 g / CF3COOH / methanol; tetrahydrofuran / 1 h / 20 °C
With
trimethylsilyl trifluoromethanesulfonate; p-Anisaldehyde dimethyl acetal; ammonia; toluene-4-sulfonic acid; bis-(trimethylsilyl)acetamide;
In
methanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1002/hlca.200390349
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 90 percent / bis(trimethylsilyl)acetamide; TMS-OTf / acetonitrile / 3 h / 60 °C
2.1: 82 percent / NH3 / methanol / 18 h / 20 °C
3.1: TsOH*H2O; p-methoxybenzaldehyde dimethyl acetal / dimethylformamide / 55 °C / 24.75 Torr
3.2: DMAP / pyridine / 16 h / 20 °C
3.3: 8.1 g / CF3COOH / methanol; tetrahydrofuran / 1 h / 20 °C
With
trimethylsilyl trifluoromethanesulfonate; p-Anisaldehyde dimethyl acetal; ammonia; toluene-4-sulfonic acid; bis-(trimethylsilyl)acetamide;
In
methanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1002/hlca.200390349
