(S)-3-(nitroxy)-2-[[1-(4-fluorophenyl)-2-methyl-5-(4-methylsulphonylphenyl)-1H-pyrrol-3-yl]acetamido]propanoic acid

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Chemical Name:(S)-3-(nitroxy)-2-[[1-(4-fluorophenyl)-2-methyl-5-(4-methylsulphonylphenyl)-1H-pyrrol-3-yl]acetamido]propanoic acid
CAS No.:1363374-35-9
Molecular Formula:C₂₃H₂₂FN₃O₈S
Molecular Weight:519.507
Hs Code.:

Synonyms:(S)-3-(nitroxy)-2-[[1-(4-fluorophenyl)-2-methyl-5-(4-methylsulphonylphenyl)-1H-pyrrol-3-yl]acetamido]propanoic acid

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Chemical Property of (S)-3-(nitroxy)-2-[[1-(4-fluorophenyl)-2-methyl-5-(4-methylsulphonylphenyl)-1H-pyrrol-3-yl]acetamido]propanoic acid

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Technology Process of (S)-3-(nitroxy)-2-[[1-(4-fluorophenyl)-2-methyl-5-(4-methylsulphonylphenyl)-1H-pyrrol-3-yl]acetamido]propanoic acid

There total 4 articles about (S)-3-(nitroxy)-2-[[1-(4-fluorophenyl)-2-methyl-5-(4-methylsulphonylphenyl)-1H-pyrrol-3-yl]acetamido]propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 927834-19-3
(2S)-2-amino-3-nitroxypropanoic acid nitrate salt

: 1346223-07-1
2-[1-(4-fluorophenyl)-2-methyl-5-[4-(methylsulfonyl)phenyl]-1H-pyrrol-3-yl]acetic acid

: 1363374-35-9
(S)-3-(nitroxy)-2-[[1-(4-fluorophenyl)-2-methyl-5-(4-methylsulphonylphenyl)-1H-pyrrol-3-yl]acetamido]propanoic acid

Guidance literature:: 2-[1-(4-fluorophenyl)-2-methyl-5-[4-(methylsulfonyl)phenyl]-1H-pyrrol-3-yl]acetic acid; With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In tetrahydrofuran; for 1h;

(2S)-2-amino-3-nitroxypropanoic acid nitrate salt; In tetrahydrofuran; at 20 ℃; for 2h;

Reference yield:

: ethyl 2-[1-(4-fluorophenyl)-2-methyl-5-[4-(methylsulfonyl)phenyl]-1H-pyrrol-3-yl]glyoxylate

: 1363374-35-9
(S)-3-(nitroxy)-2-[[1-(4-fluorophenyl)-2-methyl-5-(4-methylsulphonylphenyl)-1H-pyrrol-3-yl]acetamido]propanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylsilane; trifluoroacetic acid

2.1: sodium hydroxide; water / ethanol / 3 h / 40 °C

3.1: triethylamine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / tetrahydrofuran / 1 h

3.2: 2 h / 20 °C

With triethylsilane; water; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; ethanol;

Reference yield:

: 189500-90-1
1-(4-fluorophenyl)-2-methyl-5-[4-(methylsulfonyl)phenyl]-1H-pyrrole

: 1363374-35-9
(S)-3-(nitroxy)-2-[[1-(4-fluorophenyl)-2-methyl-5-(4-methylsulphonylphenyl)-1H-pyrrol-3-yl]acetamido]propanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: titanium tetrachloride / dichloromethane / 0 °C

2.1: triethylsilane; trifluoroacetic acid

3.1: sodium hydroxide; water / ethanol / 3 h / 40 °C

4.1: triethylamine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / tetrahydrofuran / 1 h

4.2: 2 h / 20 °C

With triethylsilane; water; titanium tetrachloride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane;