Technology Process of (R)-4-<2-(cyclopropylmethoxy)ethyl>phenyl 2,3-epoxypropyl ether
There total 7 articles about (R)-4-<2-(cyclopropylmethoxy)ethyl>phenyl 2,3-epoxypropyl ether which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium;
In
methanol; diethyl ether;
at 0 ℃;
for 12h;
DOI:10.1021/jm00389a008
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 84 percent / H2 / 5percent Pd/C / tetrahydrofuran / 50 - 60 °C / 2585.7 Torr
2: NaOH / ethanol / 24 h / Heating
3: water, HCl
4: 71 percent / pyridine / 5 h / 0 °C
5: 100 percent / Na / methanol; diethyl ether / 12 h / 0 °C
With
pyridine; hydrogenchloride; sodium hydroxide; water; hydrogen; sodium;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; diethyl ether; ethanol;
DOI:10.1021/jm00389a008
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 1.) NaH / 1.) DMF, 2.) DMF, 60 deg, 18 h
2: 84 percent / H2 / 5percent Pd/C / tetrahydrofuran / 50 - 60 °C / 2585.7 Torr
3: NaOH / ethanol / 24 h / Heating
4: water, HCl
5: 71 percent / pyridine / 5 h / 0 °C
6: 100 percent / Na / methanol; diethyl ether / 12 h / 0 °C
With
pyridine; hydrogenchloride; sodium hydroxide; water; hydrogen; sodium; sodium hydride;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; diethyl ether; ethanol;
DOI:10.1021/jm00389a008
