63659-15-4

Basic information

• Product Name: 1-(benzyloxy)-4-[2-(cyclopropylmethoxy)ethyl]benzene
• Synonyms: 1-(Benzyloxy)-4-[2-(cyclopropylmethoxy)ethyl]benzene; benzene, 1-[2-(cyclopropylmethoxy)ethyl]-4-(phenylmethoxy)-
• CAS NO: 63659-15-4
• Molecular Formula: C₁₉H₂₂O₂
• Molecular Weight: 282.3768
• Mol File: 63659-15-4.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 401.121°C at 760 mmHg
• Flash Point: 150.697°C
• Density: 1.09g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.572
• CAS DataBase Reference: 1-(benzyloxy)-4-[2-(cyclopropylmethoxy)ethyl]benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(benzyloxy)-4-[2-(cyclopropylmethoxy)ethyl]benzene(63659-15-4)
• EPA Substance Registry System: 1-(benzyloxy)-4-[2-(cyclopropylmethoxy)ethyl]benzene(63659-15-4)

Safety Data

• Hazardous Substances Data: 63659-15-4(Hazardous Substances Data)

Usage

General Description

1-(benzyloxy)-4-[2-(cyclopropylmethoxy)ethyl]benzene is a compound with a chemical structure that consists of a benzene ring attached to a benzyloxy group and a cyclopropylmethoxyethyl group. 1-(benzyloxy)-4-[2-(cyclopropylmethoxy)ethyl]benzene is commonly used in the field of organic chemistry as a building block for the synthesis of various pharmaceuticals and other organic compounds. It has been found to exhibit potential pharmacological properties, making it a valuable intermediate in the development of new drugs and therapeutic agents. Additionally, the presence of the benzyloxy and cyclopropylmethoxyethyl groups in its structure makes it a versatile starting material for the synthesis of diverse compounds with a wide range of applications.

Upstream product

• 109-99-9 tetrahydrofuran 
• 61439-59-6 2-(4-benzyloxyphenyl)ethanol 
• 7051-34-5 cyclopropylcarbinyl bromide 
• 100-39-0 benzyl bromide 
• 501-94-0 p-hydroxyphenethyl alcohol 
• 761449-63-2 1-(2-alyloxyethyl)-4-benzyloxybenzene 
• 75-11-6 diiodomethane 
• 1015-45-8 cyclopropylmethyl tosylate 

Downstream Products

• 93221-48-8 (-)-Betaxolol 
• 91878-53-4 (+)-Betaxolol 
• 108008-08-8 (R)-4-<2-(cyclopropylmethoxy)ethyl>phenyl 2,3-epoxypropyl ether 
• 104857-50-3 (5S)-5-(4-((2-cyclopropylmethoxy)ethyl)phenoxy)methyl-3-isopropyl-2-phenyloxazolidine 
• 108008-05-5 (R)-(+)-3-<4-<2-(cyclopropylmethoxy)ethyl>phenoxy>-1,2-propanodiol acetonide 
• 108008-06-6 (R)-(-)-3-<4-<2-(cyclopropylmethoxy)ethyl>phenoxy>-1,2-propanodiol 
• 63659-18-7 betaxolol 
• 63659-17-6 1-[2-(cyclopropyl-methoxy)-ethyl]-4-(2,3-epoxypropoxy)-benzene 
• 128645-29-4 1-allyloxy-4-(2-cyclopropylmethoxyethyl)benzene 
• 63659-16-5 4-[2-(cyclopropylmethoxy)-ethyl]-phenol 

Relevant articles and documents

PROCESS FOR PREPARATION OF PHENOXYPROPANOL AMINES

The present invention describes an improved method for the preparation of l-[4-{2- (cyclopropylmethoxy)ethyl}phenoxy]-3-[(1-methylethyl)amino]-2-propanol of Formula-(I) and its pharmaceutically acceptable salt, which comprises reacting 4 - [ 2 — (Cyclopropylmethoxy) ethyl] phenol with epichlorohydrin in presence of mild base and polar protic solvent to isolate 1 - {4 - [2 - (cyclopropylmethoxy)ethyl] - phenoxy} - 2, 3 - epoxy propane, which is further reacted with isopropyl amine to get betaxolol formula (I).

A convenient synthesis of the enantiomerically pure β-blocker (S)-betaxolol using hydrolytic kinetic resolution

Enantiopure (S)-betaxolol was prepared in an extremely simple and practical way using hydrolytic kinetic resolution of a terminal epoxide by Jacobsen's catalyst. High enantiomeric purity (99% ee) has been achieved and the method is amenable to industrial scale-up.

Anti-glaucoma agent

1-{4-[2-(Cyclopropylmethoxy)-ethyl]-phenoxy}-3-isopropylamino-propan-2-ol and its pharmaceutically acceptable salts, in the form of a racemate or optical isomer, are useful as topical anti-glaucoma agents.