63659-15-4

Usage

Chemical structure

1-(benzyloxy)-4-[2-(cyclopropylmethoxy)ethyl]benzene consists of a benzene ring attached to a benzyloxy group and a cyclopropylmethoxyethyl group.

Application in organic chemistry

It is commonly used as a building block for the synthesis of various pharmaceuticals and other organic compounds.

Pharmacological properties

The compound has been found to exhibit potential pharmacological properties.

Intermediate in drug development

It is a valuable intermediate in the development of new drugs and therapeutic agents.

Versatility

The presence of the benzyloxy and cyclopropylmethoxyethyl groups in its structure makes it a versatile starting material for the synthesis of diverse compounds.

Wide range of applications

Due to its versatility, it has a wide range of applications in the synthesis of various compounds.

Upstream product

• 61439-59-6 2-(4-benzyloxyphenyl)ethanol 
• 1015-45-8 cyclopropylmethyl tosylate 
• 761449-63-2 1-(2-alyloxyethyl)-4-benzyloxybenzene 
• 75-11-6 diiodomethane 
• 100-39-0 benzyl bromide 
• 109-99-9 tetrahydrofuran 
• 7051-34-5 cyclopropylcarbinyl bromide 
• 501-94-0 p-hydroxyphenethyl alcohol 

Downstream Products

• 63659-16-5 4-[2-(cyclopropylmethoxy)-ethyl]-phenol 
• 128645-29-4 1-allyloxy-4-(2-cyclopropylmethoxyethyl)benzene 
• 63659-17-6 1-[2-(cyclopropyl-methoxy)-ethyl]-4-(2,3-epoxypropoxy)-benzene 
• 93221-48-8 (-)-Betaxolol 
• 91878-53-4 (+)-Betaxolol 
• 108008-08-8 (R)-4-<2-(cyclopropylmethoxy)ethyl>phenyl 2,3-epoxypropyl ether 
• 104857-50-3 (5S)-5-(4-((2-cyclopropylmethoxy)ethyl)phenoxy)methyl-3-isopropyl-2-phenyloxazolidine 
• 108008-05-5 (R)-(+)-3-<4-<2-(cyclopropylmethoxy)ethyl>phenoxy>-1,2-propanodiol acetonide 
• 108008-06-6 (R)-(-)-3-<4-<2-(cyclopropylmethoxy)ethyl>phenoxy>-1,2-propanodiol 
• 63659-18-7 betaxolol 

Relevant academic research and scientific papers

PROCESS FOR PREPARATION OF PHENOXYPROPANOL AMINES

The present invention describes an improved method for the preparation of l-[4-{2- (cyclopropylmethoxy)ethyl}phenoxy]-3-[(1-methylethyl)amino]-2-propanol of Formula-(I) and its pharmaceutically acceptable salt, which comprises reacting 4 - [ 2 — (Cyclopropylmethoxy) ethyl] phenol with epichlorohydrin in presence of mild base and polar protic solvent to isolate 1 - {4 - [2 - (cyclopropylmethoxy)ethyl] - phenoxy} - 2, 3 - epoxy propane, which is further reacted with isopropyl amine to get betaxolol formula (I).

PROCESS FOR PREPARATION OF S-(-)-BETAXOLOL AND SALTS THEREOF

The present invention relates to an improved process for preparation of S-(?)-betaxolol salts. More particularly the present invention relates to the preparation of hydrochloride salt of S-(?)-betaxolol of formula (1).

A convenient synthesis of the enantiomerically pure β-blocker (S)-betaxolol using hydrolytic kinetic resolution

Enantiopure (S)-betaxolol was prepared in an extremely simple and practical way using hydrolytic kinetic resolution of a terminal epoxide by Jacobsen's catalyst. High enantiomeric purity (99% ee) has been achieved and the method is amenable to industrial scale-up.

Anti-glaucoma agent

1-{4-[2-(Cyclopropylmethoxy)-ethyl]-phenoxy}-3-isopropylamino-propan-2-ol and its pharmaceutically acceptable salts, in the form of a racemate or optical isomer, are useful as topical anti-glaucoma agents.

PHENOL ETHERS

The invention provides phenol ethers of the formula: STR1 wherein R is branched C 3-4 alkyl, C 3-4 cycloalkyl, branched cyano(C 3-4 alkyl), phenyl(C 2-3 alkyl), halophenyl(C 2-3 alkyl), (C 1-4 alkoxy)phenyl(C 2-4 alkyl), or (C 1-4 acyl) amino(C 1-4 alkyl),alk is C 1-4 alkyl substituted by a 3 to 6 membered cycloalkyl group,X is--O--,--S--or--SO 2--; andR 1 is--C 1-4 alkyl-or--C 1-4 alkoxy-, in their racemic and optically active forms, and their addition salts with pharmaceutically acceptable acids. These compounds are useful in therapy as β-adrenergic blocking agents. Intermediates are also provided.