1-{(E)-3-[Bis-(2-hydroxy-ethyl)-amino]-propylimino}-7-chloro-3-(2,4-dichloro-phenyl)-1,3,4,10-tetrahydro-2H-acridin-9-one

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Chemical Name:1-{(E)-3-[Bis-(2-hydroxy-ethyl)-amino]-propylimino}-7-chloro-3-(2,4-dichloro-phenyl)-1,3,4,10-tetrahydro-2H-acridin-9-one
CAS No.:144155-59-9
Molecular Formula:C₂₆H₂₈Cl₃N₃O₃
Molecular Weight:536.886
Hs Code.:

Synonyms:1-{(E)-3-[Bis-(2-hydroxy-ethyl)-amino]-propylimino}-7-chloro-3-(2,4-dichloro-phenyl)-1,3,4,10-tetrahydro-2H-acridin-9-one

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Chemical Property of 1-{(E)-3-[Bis-(2-hydroxy-ethyl)-amino]-propylimino}-7-chloro-3-(2,4-dichloro-phenyl)-1,3,4,10-tetrahydro-2H-acridin-9-one

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Technology Process of 1-{(E)-3-[Bis-(2-hydroxy-ethyl)-amino]-propylimino}-7-chloro-3-(2,4-dichloro-phenyl)-1,3,4,10-tetrahydro-2H-acridin-9-one

There total 7 articles about 1-{(E)-3-[Bis-(2-hydroxy-ethyl)-amino]-propylimino}-7-chloro-3-(2,4-dichloro-phenyl)-1,3,4,10-tetrahydro-2H-acridin-9-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 91700-87-7
7-chloro-3-(2,4-dichlorophenyl)-1,2,3,4,9,10-hexahydroacridine-1,9-dione

: 4985-85-7
2,2'-[(3-aminopropyl)imino]bis-ethanol

: 144155-59-9
1-{(E)-3-[Bis-(2-hydroxy-ethyl)-amino]-propylimino}-7-chloro-3-(2,4-dichloro-phenyl)-1,3,4,10-tetrahydro-2H-acridin-9-one

Guidance literature:: In N,N-dimethyl-formamide; for 1.5h; Heating;
DOI:10.1021/jm00097a001

Reference yield:

: 4743-17-3
5-Chloroisatoic anhydride

: 144155-59-9
1-{(E)-3-[Bis-(2-hydroxy-ethyl)-amino]-propylimino}-7-chloro-3-(2,4-dichloro-phenyl)-1,3,4,10-tetrahydro-2H-acridin-9-one

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) 50percent NaH / 1.) DMF, RT, 1 h, 2.) DMF, 90 deg C, 4 h

2: 80 percent / dimethylformamide / 1.5 h / Heating

With sodium hydride; In N,N-dimethyl-formamide;
DOI:10.1021/jm00097a001

Reference yield:

: 66896-92-2,61888-78-6
4-(2',4'-dichlorophenyl)-3-buten-2-one

: 144155-59-9
1-{(E)-3-[Bis-(2-hydroxy-ethyl)-amino]-propylimino}-7-chloro-3-(2,4-dichloro-phenyl)-1,3,4,10-tetrahydro-2H-acridin-9-one

Guidance literature:: Multi-step reaction with 5 steps

1: EtONa / ethanol / 6 h / Heating

2: 2 N NaOH / 2 h / Heating

3: 5 N H₂SO₄ / 4.5 h / Heating

4: 1.) 50percent NaH / 1.) DMF, RT, 1 h, 2.) DMF, 90 deg C, 4 h

5: 80 percent / dimethylformamide / 1.5 h / Heating

With sodium hydroxide; sulfuric acid; sodium ethanolate; sodium hydride; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00097a001