2-[2-[2-bromo-4-methoxy-5-(1-methylethoxy)phenyl]ethyl]-2-[4-(1-methylethoxy)phenylmethyl]propane-1,3-dicarboxylic acid dimethyl ester

Base Information

• Chemical Name: 2-[2-[2-bromo-4-methoxy-5-(1-methylethoxy)phenyl]ethyl]-2-[4-(1-methylethoxy)phenylmethyl]propane-1,3-dicarboxylic acid dimethyl ester
• CAS No.: 365572-26-5
• Molecular Formula: C₂₇H₃₅BrO₇
• Molecular Weight: 551.475
• Mol file: 365572-26-5.mol

Synonyms:2-[2-[2-bromo-4-methoxy-5-(1-methylethoxy)phenyl]ethyl]-2-[4-(1-methylethoxy)phenylmethyl]propane-1,3-dicarboxylic acid dimethyl ester

Chemical Property of 2-[2-[2-bromo-4-methoxy-5-(1-methylethoxy)phenyl]ethyl]-2-[4-(1-methylethoxy)phenylmethyl]propane-1,3-dicarboxylic acid dimethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[2-[2-bromo-4-methoxy-5-(1-methylethoxy)phenyl]ethyl]-2-[4-(1-methylethoxy)phenylmethyl]propane-1,3-dicarboxylic acid dimethyl ester

There total 6 articles about 2-[2-[2-bromo-4-methoxy-5-(1-methylethoxy)phenyl]ethyl]-2-[4-(1-methylethoxy)phenylmethyl]propane-1,3-dicarboxylic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

1-(Chloromethyl)-4-(1-methylethoxy)benzene (40141-12-6) + 2-[2-[2-bromo-4-methoxy-5-(1-methylethoxy)phenyl]ethyl]propane-1,3-dicarboxylic acid dimethyl ester (365572-25-4) → 2-[2-[2-bromo-4-methoxy-5-(1-methylethoxy)phenyl]ethyl]-2-[4-(1-methylethoxy)phenylmethyl]propane-1,3-dicarboxylic acid dimethyl ester (365572-26-5)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 12h;

DOI:10.3390/70400374

Reference yield:

malonic acid dimethyl ester (108-59-8) → 2-[2-[2-bromo-4-methoxy-5-(1-methylethoxy)phenyl]ethyl]-2-[4-(1-methylethoxy)phenylmethyl]propane-1,3-dicarboxylic acid dimethyl ester (365572-26-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 72 percent / potassium carbonate / dimethylformamide / 12 h / 80 °C

2: 91 percent / potassium carbonate / dimethylformamide / 12 h / 80 °C

With potassium carbonate; In N,N-dimethyl-formamide;

DOI:10.3390/70400374

Reference yield:

2-bromo-4-methoxy-5-(1-methylethoxy)benzeneacetaldehyde (365572-22-1) → 2-[2-[2-bromo-4-methoxy-5-(1-methylethoxy)phenyl]ethyl]-2-[4-(1-methylethoxy)phenylmethyl]propane-1,3-dicarboxylic acid dimethyl ester (365572-26-5)

Guidance literature:

Multi-step reaction with 4 steps

1: 99 percent / sodium borohydride / ethanol / 2 h / 15 °C

2: 77 percent / imidazole; iodine; triphenylphosphine / CH₂Cl₂ / 2 h / 20 °C

3: 72 percent / potassium carbonate / dimethylformamide / 12 h / 80 °C

4: 91 percent / potassium carbonate / dimethylformamide / 12 h / 80 °C

With 1H-imidazole; sodium tetrahydroborate; iodine; potassium carbonate; triphenylphosphine; In ethanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.3390/70400374

upstream raw materials:

1-(Chloromethyl)-4-(1-methylethoxy)benzene

2-[2-[2-bromo-4-methoxy-5-(1-methylethoxy)phenyl]ethyl]propane-1,3-dicarboxylic acid dimethyl ester

malonic acid dimethyl ester

2-bromo-4-methoxy-5-(1-methylethoxy)benzeneacetaldehyde

Downstream raw materials:

4-(2-bromo-5-isopropoxy-4-methoxy-phenyl)-2-(4-isopropoxy-benzyl)-butyric acid

4-(2-bromo-5-isopropoxy-4-methoxy-phenyl)-2-(4-isopropoxy-benzyl)-butyramide

4-(2-bromo-5-hydroxy-4-methoxy-phenyl)-2-(4-hydroxy-benzyl)-butyramide