Technology Process of (R)-N-carbamoyl-5-(4,4-difluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide
There total 13 articles about (R)-N-carbamoyl-5-(4,4-difluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
ammonium hydroxide; ammonium chloride;
at 20 ℃;
for 1h;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: triethylamine; methanesulfonyl chloride / dichloromethane / 1 h / -60 °C / Inert atmosphere
2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C
2.2: 20 °C
3.1: trichloroisocyanuric acid / 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / dichloromethane / 1.25 h / -10 - 20 °C
4.1: diethylamino-sulfur trifluoride / dichloromethane / 2.5 h / -78 - 20 °C / Plastic bottle
5.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C
5.2: 0 °C
6.1: potassium fluoride / dimethyl sulfoxide / 2 h / 85 °C
7.1: 4 h / 85 °C
8.1: ammonium hydroxide; ammonium chloride / 1 h / 20 °C
With
potassium fluoride; ammonium hydroxide; diethylamino-sulfur trifluoride; trichloroisocyanuric acid; tetrabutyl ammonium fluoride; ammonium chloride; methanesulfonyl chloride; triethylamine; trifluoroacetic acid;
2,2,6,6-Tetramethyl-1-piperidinyloxy free radical;
In
tetrahydrofuran; dichloromethane; dimethyl sulfoxide;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: trichloroisocyanuric acid / 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / dichloromethane / 1.25 h / -10 - 20 °C
2.1: diethylamino-sulfur trifluoride / dichloromethane / 2.5 h / -78 - 20 °C / Plastic bottle
3.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C
3.2: 0 °C
4.1: potassium fluoride / dimethyl sulfoxide / 2 h / 85 °C
5.1: 4 h / 85 °C
6.1: ammonium hydroxide; ammonium chloride / 1 h / 20 °C
With
potassium fluoride; ammonium hydroxide; diethylamino-sulfur trifluoride; trichloroisocyanuric acid; ammonium chloride; trifluoroacetic acid;
2,2,6,6-Tetramethyl-1-piperidinyloxy free radical;
In
dichloromethane; dimethyl sulfoxide;
