(R)-tert-butyl 4,4-difluoro-2-(3-fluorophenyl)pyrrolidine-1-carboxylate

Base Information

Chemical Name:(R)-tert-butyl 4,4-difluoro-2-(3-fluorophenyl)pyrrolidine-1-carboxylate
CAS No.:1223404-95-2
Molecular Formula:C₁₅H₁₈F₃NO₂
Molecular Weight:301.309
Hs Code.:

Synonyms:(R)-tert-butyl 4,4-difluoro-2-(3-fluorophenyl)pyrrolidine-1-carboxylate

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Chemical Property of (R)-tert-butyl 4,4-difluoro-2-(3-fluorophenyl)pyrrolidine-1-carboxylate

Chemical Property:

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Technology Process of (R)-tert-butyl 4,4-difluoro-2-(3-fluorophenyl)pyrrolidine-1-carboxylate

There total 5 articles about (R)-tert-butyl 4,4-difluoro-2-(3-fluorophenyl)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1223404-93-0
(R)-tert-butyl 2-(3-fluorophenyl)-4-oxopyrrolidine-1-carboxylate

: 1223404-95-2
(R)-tert-butyl 4,4-difluoro-2-(3-fluorophenyl)pyrrolidine-1-carboxylate

Guidance literature:: With (bis-(2-methoxyethyl)amino)sulfur trufluoride; In dichloromethane; at 20 ℃;

Reference yield:

: 1223404-92-9
(2R,4R)-tert-butyl 2-(3-fluorophenyl)-4-hydroxypyrrolidine-1-carboxylate

: 1223404-95-2
(R)-tert-butyl 4,4-difluoro-2-(3-fluorophenyl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: trichloroisocyanuric acid; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / dichloromethane / 1.25 h / -10 - 20 °C

2: diethylamino-sulfur trifluoride / dichloromethane / 2.5 h / -78 - 20 °C

With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; diethylamino-sulfur trifluoride; trichloroisocyanuric acid; In dichloromethane;

Reference yield:

: 228267-20-7
tert-butyl (R)-4-((tert-butyldimethylsilyl)oxy)-2-oxopyrrolidine-1-carboxylate

: 1223404-95-2
(R)-tert-butyl 4,4-difluoro-2-(3-fluorophenyl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetrahydrofuran / 2 h / 0 °C / Inert atmosphere

1.2: 1 h / 0 °C

2.1: triethylamine; methanesulfonyl chloride / dichloromethane / 1 h / -60 °C / Inert atmosphere

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C

3.2: 20 °C

4.1: trichloroisocyanuric acid / 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / dichloromethane / 1.25 h / -10 - 20 °C

5.1: diethylamino-sulfur trifluoride / dichloromethane / 2.5 h / -78 - 20 °C / Plastic bottle

With diethylamino-sulfur trifluoride; trichloroisocyanuric acid; tetrabutyl ammonium fluoride; methanesulfonyl chloride; triethylamine; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; In tetrahydrofuran; dichloromethane;