4-{4-[(S)-1-((S)-5-tert-butoxycarbonylamino-1-propoxycarbonylpentylcarbamoyl)-3-methylbutylcarbamoyl]phenoxy}benzoic acid benzyl ester

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Chemical Name:4-{4-[(S)-1-((S)-5-tert-butoxycarbonylamino-1-propoxycarbonylpentylcarbamoyl)-3-methylbutylcarbamoyl]phenoxy}benzoic acid benzyl ester
CAS No.:918797-45-2
Molecular Formula:C₄₁H₅₃N₃O₉
Molecular Weight:731.887
Hs Code.:

Synonyms:4-{4-[(S)-1-((S)-5-tert-butoxycarbonylamino-1-propoxycarbonylpentylcarbamoyl)-3-methylbutylcarbamoyl]phenoxy}benzoic acid benzyl ester

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Chemical Property of 4-{4-[(S)-1-((S)-5-tert-butoxycarbonylamino-1-propoxycarbonylpentylcarbamoyl)-3-methylbutylcarbamoyl]phenoxy}benzoic acid benzyl ester

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Technology Process of 4-{4-[(S)-1-((S)-5-tert-butoxycarbonylamino-1-propoxycarbonylpentylcarbamoyl)-3-methylbutylcarbamoyl]phenoxy}benzoic acid benzyl ester

There total 7 articles about 4-{4-[(S)-1-((S)-5-tert-butoxycarbonylamino-1-propoxycarbonylpentylcarbamoyl)-3-methylbutylcarbamoyl]phenoxy}benzoic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-amino-6-tert-butoxycarbonylamino-hexanoic acid propyl ester

: 918797-45-2
4-{4-[(S)-1-((S)-5-tert-butoxycarbonylamino-1-propoxycarbonylpentylcarbamoyl)-3-methylbutylcarbamoyl]phenoxy}benzoic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: N-methylmorpholine; 1-hydroxybenzotriazole; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium*PF₆ / dimethylformamide

2: H₂ / Pd/C / methanol

3: 380 mg / N-methylmorpholine; 1-hydroxybenzotriazole; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium*PF₆ / dimethylformamide

With 4-methyl-morpholine; hydrogen; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm061033d

Reference yield:

: carboxybenzyl-L-lysine allyl ester

: 918797-45-2
4-{4-[(S)-1-((S)-5-tert-butoxycarbonylamino-1-propoxycarbonylpentylcarbamoyl)-3-methylbutylcarbamoyl]phenoxy}benzoic acid benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: Et₃N / CH₂Cl₂ / 12 h / 20 °C

2: H₂ / Pd/C / methanol

3: N-methylmorpholine; 1-hydroxybenzotriazole; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium*PF₆ / dimethylformamide

4: H₂ / Pd/C / methanol

5: 380 mg / N-methylmorpholine; 1-hydroxybenzotriazole; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium*PF₆ / dimethylformamide

With 4-methyl-morpholine; hydrogen; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm061033d

Reference yield:

: 918797-43-0
(S)-2-benzyloxycarbonylamino-6-tert-butoxycarbonylaminohexanoic acid allyl ester

: 918797-45-2
4-{4-[(S)-1-((S)-5-tert-butoxycarbonylamino-1-propoxycarbonylpentylcarbamoyl)-3-methylbutylcarbamoyl]phenoxy}benzoic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: H₂ / Pd/C / methanol

2: N-methylmorpholine; 1-hydroxybenzotriazole; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium*PF₆ / dimethylformamide

3: H₂ / Pd/C / methanol

4: 380 mg / N-methylmorpholine; 1-hydroxybenzotriazole; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium*PF₆ / dimethylformamide

With 4-methyl-morpholine; hydrogen; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm061033d