tert-butyl 3-((1R)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-hydroxyethyl)-5-(trifluoromethyl)benzoate

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Chemical Name:tert-butyl 3-((1R)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-hydroxyethyl)-5-(trifluoromethyl)benzoate
CAS No.:1237536-02-5
Molecular Formula:C₂₀H₃₁F₃O₄Si
Molecular Weight:420.544
Hs Code.:

Synonyms:tert-butyl 3-((1R)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-hydroxyethyl)-5-(trifluoromethyl)benzoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of tert-butyl 3-((1R)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-hydroxyethyl)-5-(trifluoromethyl)benzoate

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Technology Process of tert-butyl 3-((1R)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-hydroxyethyl)-5-(trifluoromethyl)benzoate

There total 3 articles about tert-butyl 3-((1R)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-hydroxyethyl)-5-(trifluoromethyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1237536-00-3
tert-butyl 3-(trifluoromethyl)-5-vinylbenzoate

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1237536-02-5
tert-butyl 3-((1R)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-hydroxyethyl)-5-(trifluoromethyl)benzoate

Guidance literature:: tert-butyl 3-(trifluoromethyl)-5-vinylbenzoate; With hydroquinine 1,4-phthalazinediyl diether; In water; tert-butyl alcohol; at 20 ℃;

tert-butyldimethylsilyl chloride; With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; for 4h;
DOI:10.1016/j.bmcl.2016.01.049

Reference yield: 85.9%

: 1237536-01-4
tert-butyl 3-[(1R)-1,2-dihydroxyethyl]-5-(trifluoromethyl)benzoate

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1237536-02-5
tert-butyl 3-((1R)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-hydroxyethyl)-5-(trifluoromethyl)benzoate

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 0 - 20 ℃;

Reference yield:

: 328-67-6
3-bromo-5-(trifluoromethyl)benzoic acid

: 1237536-02-5
tert-butyl 3-((1R)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-hydroxyethyl)-5-(trifluoromethyl)benzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide; dichloromethane / 18 h / 20 °C

1.2: 1 h / 0 °C

2.1: palladium dichloride; triphenylphosphine; caesium carbonate / tetrahydrofuran; water / 85 °C

3.1: hydroquinine 1,4-phthalazinediyl diether / water; tert-butyl alcohol / 20 °C

3.2: 4 h / 20 °C

With oxalyl dichloride; hydroquinine 1,4-phthalazinediyl diether; caesium carbonate; triphenylphosphine; palladium dichloride; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol; 2.1: |Suzuki Coupling / 3.1: |Sharpless Dihydroxylation;
DOI:10.1016/j.bmcl.2016.01.049