4-(4-hydroxyphenyl)butyric acid (3-methoxybenzylidene)hydrazide

Base Information

• Chemical Name: 4-(4-hydroxyphenyl)butyric acid (3-methoxybenzylidene)hydrazide
• CAS No.: 425672-37-3
• Molecular Formula: C₁₈H₂₀N₂O₃
• Molecular Weight: 312.368
• Mol file: 425672-37-3.mol

Synonyms:4-(4-hydroxyphenyl)butyric acid (3-methoxybenzylidene)hydrazide

Chemical Property of 4-(4-hydroxyphenyl)butyric acid (3-methoxybenzylidene)hydrazide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 4-(4-hydroxyphenyl)butyric acid (3-methoxybenzylidene)hydrazide

There total 1 articles about 4-(4-hydroxyphenyl)butyric acid (3-methoxybenzylidene)hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

3-methoxy-benzaldehyde (591-31-1) + 4-(4-hydroxyphenyl)butyric acid hydrazide (425675-10-1) → 4-(4-hydroxyphenyl)butyric acid (3-methoxybenzylidene)hydrazide (425672-37-3)

Guidance literature:

With toluene-4-sulfonic acid; In isopropyl alcohol; at 20 ℃; for 20h;

DOI:10.1021/jm034173l

Reference yield:

4-(4-hydroxyphenyl)butyric acid (3-methoxybenzylidene)hydrazide (425672-37-3) → 4-(4-hydroxyphenyl)butyric acid N'-(3-methoxybenzyl)hydrazide (425672-43-1)

Guidance literature:

With sodium cyanoborohydride; acetic acid; In tetrahydrofuran; isopropyl alcohol; at 20 ℃; for 30h;

DOI:10.1021/jm034173l

Reference yield:

4-(4-hydroxyphenyl)butyric acid (3-methoxybenzylidene)hydrazide (425672-37-3) → 2-(4-{3-[1-(3-methoxy-benzyl)-5-oxo-4-propyl-4,5-dihydro-1H-[1,2,4]triazol-3-yl]-propyl}-phenoxy)-2-methyl-propionic acid

Guidance literature:

Multi-step reaction with 5 steps

1: sodium cyanoborohydride; acetic acid / propan-2-ol; tetrahydrofuran / 30 h / 20 °C

2: tetrahydrofuran / 16 h

3: 60 percent / aq. KOH / methanol / 24 h / Heating

4: 77 percent / K₂CO₃; MgSO₄ / ethanol / 16 h / 80 °C

5: 97 percent / aq. NaOH / methanol / 16 h / 20 °C

With potassium hydroxide; sodium hydroxide; sodium cyanoborohydride; magnesium sulfate; potassium carbonate; acetic acid; In tetrahydrofuran; methanol; ethanol; isopropyl alcohol;

DOI:10.1021/jm034173l

upstream raw materials:

3-methoxy-benzaldehyde

4-(4-hydroxyphenyl)butyric acid hydrazide

Downstream raw materials:

4-(4-hydroxyphenyl)butyric acid N'-(3-methoxybenzyl)hydrazide

5-[3-(4-hydroxyphenyl)propyl]-2-(3-methoxybenzyl)-4-propyl-2,4-dihydro[1,2,4]triazol-3-one

N'-[4-(4-hydroxyphenyl)butyryl]-N-(3-methoxybenzyl)hydrazinecarboxylic acid n-propyl amide

2-(4-{3-[1-(3-methoxybenzyl)-5-oxo-4-propyl-4,5-dihydro-1H-[1,2,4]triazol-3-yl]propyl}phenoxy)-2-methylpropionic acid ethyl ester