5-[3-(4-hydroxyphenyl)propyl]-2-(3-methoxybenzyl)-4-propyl-2,4-dihydro[1,2,4]triazol-3-one

Base Information

• Chemical Name: 5-[3-(4-hydroxyphenyl)propyl]-2-(3-methoxybenzyl)-4-propyl-2,4-dihydro[1,2,4]triazol-3-one
• CAS No.: 425672-55-5
• Molecular Formula: C₂₂H₂₇N₃O₃
• Molecular Weight: 381.475

Synonyms:5-[3-(4-hydroxyphenyl)propyl]-2-(3-methoxybenzyl)-4-propyl-2,4-dihydro[1,2,4]triazol-3-one

Chemical Property of 5-[3-(4-hydroxyphenyl)propyl]-2-(3-methoxybenzyl)-4-propyl-2,4-dihydro[1,2,4]triazol-3-one

Chemical Property:

Purity/Quality:

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Technology Process of 5-[3-(4-hydroxyphenyl)propyl]-2-(3-methoxybenzyl)-4-propyl-2,4-dihydro[1,2,4]triazol-3-one

There total 5 articles about 5-[3-(4-hydroxyphenyl)propyl]-2-(3-methoxybenzyl)-4-propyl-2,4-dihydro[1,2,4]triazol-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

N'-[4-(4-hydroxyphenyl)butyryl]-N-(3-methoxybenzyl)hydrazinecarboxylic acid n-propyl amide (425672-49-7) → 5-[3-(4-hydroxyphenyl)propyl]-2-(3-methoxybenzyl)-4-propyl-2,4-dihydro[1,2,4]triazol-3-one (425672-55-5)

Guidance literature:

With potassium hydroxide; In methanol; for 24h; Heating;

DOI:10.1021/jm034173l

Reference yield:

3-methoxy-benzaldehyde (591-31-1) → 5-[3-(4-hydroxyphenyl)propyl]-2-(3-methoxybenzyl)-4-propyl-2,4-dihydro[1,2,4]triazol-3-one (425672-55-5)

Guidance literature:

Multi-step reaction with 4 steps

1: 86 percent / p-toluenesulfonic acid / propan-2-ol / 20 h / 20 °C

2: sodium cyanoborohydride; acetic acid / propan-2-ol; tetrahydrofuran / 30 h / 20 °C

3: tetrahydrofuran / 16 h

4: 60 percent / aq. KOH / methanol / 24 h / Heating

With potassium hydroxide; sodium cyanoborohydride; toluene-4-sulfonic acid; acetic acid; In tetrahydrofuran; methanol; isopropyl alcohol;

DOI:10.1021/jm034173l

Reference yield:

4-(4-hydroxyphenyl)butyric acid hydrazide (425675-10-1) → 5-[3-(4-hydroxyphenyl)propyl]-2-(3-methoxybenzyl)-4-propyl-2,4-dihydro[1,2,4]triazol-3-one (425672-55-5)

Guidance literature:

Multi-step reaction with 4 steps

1: 86 percent / p-toluenesulfonic acid / propan-2-ol / 20 h / 20 °C

2: sodium cyanoborohydride; acetic acid / propan-2-ol; tetrahydrofuran / 30 h / 20 °C

3: tetrahydrofuran / 16 h

4: 60 percent / aq. KOH / methanol / 24 h / Heating

With potassium hydroxide; sodium cyanoborohydride; toluene-4-sulfonic acid; acetic acid; In tetrahydrofuran; methanol; isopropyl alcohol;

DOI:10.1021/jm034173l

upstream raw materials:

N'-[4-(4-hydroxyphenyl)butyryl]-N-(3-methoxybenzyl)hydrazinecarboxylic acid n-propyl amide

3-methoxy-benzaldehyde

4-(4-hydroxyphenyl)butyric acid hydrazide

4-(4-hydroxyphenyl)butyric acid (3-methoxybenzylidene)hydrazide

Downstream raw materials:

2-(4-{3-[1-(3-methoxybenzyl)-5-oxo-4-propyl-4,5-dihydro-1H-[1,2,4]triazol-3-yl]propyl}phenoxy)-2-methylpropionic acid ethyl ester

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