methyl 2-(4-chlorophenyl)-2-(1-methyl-1H-indol-5-yl)-3-phenylpropanoate

Base Information

Chemical Name:methyl 2-(4-chlorophenyl)-2-(1-methyl-1H-indol-5-yl)-3-phenylpropanoate
CAS No.:1334531-97-3
Molecular Formula:C₂₅H₂₂ClNO₂
Molecular Weight:403.908
Hs Code.:

Synonyms:methyl 2-(4-chlorophenyl)-2-(1-methyl-1H-indol-5-yl)-3-phenylpropanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl 2-(4-chlorophenyl)-2-(1-methyl-1H-indol-5-yl)-3-phenylpropanoate

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Technology Process of methyl 2-(4-chlorophenyl)-2-(1-methyl-1H-indol-5-yl)-3-phenylpropanoate

There total 2 articles about methyl 2-(4-chlorophenyl)-2-(1-methyl-1H-indol-5-yl)-3-phenylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 837392-62-8
1-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole

: 100-39-0
benzyl bromide

: 93961-29-6
methyl 2-(4-chlorophenyl)-2-diazoacetate

: 1334531-97-3
methyl 2-(4-chlorophenyl)-2-(1-methyl-1H-indol-5-yl)-3-phenylpropanoate

Guidance literature:: With [Rh(OH)(cod)]2; potassium tert-butylate; In tert-butyl methyl ether; at 20 - 40 ℃; for 4h; Inert atmosphere;
DOI:10.1021/ol2022577

Reference yield:

: 52449-43-1
(4-chloro-phenyl)-acetic acid methyl ester

: 1334531-97-3
methyl 2-(4-chlorophenyl)-2-(1-methyl-1H-indol-5-yl)-3-phenylpropanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 4-acetamidobenzenesulfonyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 20 °C / Inert atmosphere

2: [Rh(OH)(cod)]2; potassium tert-butylate / tert-butyl methyl ether / 4 h / 20 - 40 °C / Inert atmosphere

With [Rh(OH)(cod)]2; 4-acetamidobenzenesulfonyl azide; potassium tert-butylate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tert-butyl methyl ether; acetonitrile;
DOI:10.1021/ol2022577