3-(2-(6-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)-2-(trifluoromethyl)pyridin-3-yl)cyclopropyl)benzoic acid

Base Information

Chemical Name:3-(2-(6-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)-2-(trifluoromethyl)pyridin-3-yl)cyclopropyl)benzoic acid
CAS No.:1268245-17-5
Molecular Formula:C₂₉H₂₁Cl₂F₃N₂O₄
Molecular Weight:589.398
Hs Code.:

Synonyms:3-(2-(6-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)-2-(trifluoromethyl)pyridin-3-yl)cyclopropyl)benzoic acid

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Chemical Property of 3-(2-(6-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)-2-(trifluoromethyl)pyridin-3-yl)cyclopropyl)benzoic acid

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Technology Process of 3-(2-(6-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)-2-(trifluoromethyl)pyridin-3-yl)cyclopropyl)benzoic acid

There total 19 articles about 3-(2-(6-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)-2-(trifluoromethyl)pyridin-3-yl)cyclopropyl)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.1%

: C₃₀H₂₃Cl₂F₃N₂O₄

: 1268245-17-5
3-(2-(6-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)-2-(trifluoromethyl)pyridin-3-yl)cyclopropyl)benzoic acid

Guidance literature:: C₃₀H₂₃Cl₂F₃N₂O₄; With lithium hydroxide monohydrate; water; In tetrahydrofuran; at 20 ℃; for 24h;

With hydrogenchloride; In water; pH=5;

Reference yield:

: 1877-71-0
benzene 1,3-dicarboxylic acid monomethyl ester

: 1268245-17-5
3-(2-(6-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)-2-(trifluoromethyl)pyridin-3-yl)cyclopropyl)benzoic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: borane-THF / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2.1: phosphorus tribromide / diethyl ether / 2 h

3.1: 4 h / 175 °C

4.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C

4.2: 0 - 20 °C

5.1: palladium diacetate / diethyl ether / -50 - 20 °C / Inert atmosphere

6.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 24 h / 20 °C

6.2: pH 5

With borane-THF; lithium hydroxide monohydrate; water; phosphorus tribromide; sodium hydride; palladium diacetate; In tetrahydrofuran; diethyl ether; mineral oil;

Reference yield:

: 1129-28-8
3-methoxycarbonylbenzyl bromide

: 1268245-17-5
3-(2-(6-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)-2-(trifluoromethyl)pyridin-3-yl)cyclopropyl)benzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: 4 h / 175 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C

2.2: 0 - 20 °C

3.1: palladium diacetate / diethyl ether / -50 - 20 °C / Inert atmosphere

4.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 24 h / 20 °C

4.2: pH 5

With lithium hydroxide monohydrate; water; sodium hydride; palladium diacetate; In tetrahydrofuran; diethyl ether; mineral oil;