N-[[5-tert-butyl-2-(3-chlorophenyl)-2H-pyrazol-3-yl]methyl]-2-[3-fluoro-4-(1-hydroxycyclopropyl)phenyl]propionamide

Base Information

Chemical Name:N-[[5-tert-butyl-2-(3-chlorophenyl)-2H-pyrazol-3-yl]methyl]-2-[3-fluoro-4-(1-hydroxycyclopropyl)phenyl]propionamide
CAS No.:1402581-37-6
Molecular Formula:C₂₆H₂₉ClFN₃O₂
Molecular Weight:469.987
Hs Code.:

Synonyms:N-[[5-tert-butyl-2-(3-chlorophenyl)-2H-pyrazol-3-yl]methyl]-2-[3-fluoro-4-(1-hydroxycyclopropyl)phenyl]propionamide

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Chemical Property of N-[[5-tert-butyl-2-(3-chlorophenyl)-2H-pyrazol-3-yl]methyl]-2-[3-fluoro-4-(1-hydroxycyclopropyl)phenyl]propionamide

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Technology Process of N-[[5-tert-butyl-2-(3-chlorophenyl)-2H-pyrazol-3-yl]methyl]-2-[3-fluoro-4-(1-hydroxycyclopropyl)phenyl]propionamide

There total 17 articles about N-[[5-tert-butyl-2-(3-chlorophenyl)-2H-pyrazol-3-yl]methyl]-2-[3-fluoro-4-(1-hydroxycyclopropyl)phenyl]propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 1402585-45-8
N-((3-tert-butyl-1-(3-chlorophenyl)-1H-pyrazol-5-yl)methyl)-2-(4-(1-(tert-butyldimethylsilyloxy)cyclopropyl)-3-fluorophenyl)propanamide

: 1402581-37-6
N-[[5-tert-butyl-2-(3-chlorophenyl)-2H-pyrazol-3-yl]methyl]-2-[3-fluoro-4-(1-hydroxycyclopropyl)phenyl]propionamide

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 23 ℃; for 5h;

Reference yield:

: 82560-12-1,1237537-54-0
3-tert-butyl-1H-pyrazole-5-amine

: 1402581-37-6
N-[[5-tert-butyl-2-(3-chlorophenyl)-2H-pyrazol-3-yl]methyl]-2-[3-fluoro-4-(1-hydroxycyclopropyl)phenyl]propionamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogenchloride; sodium nitrite / water / 1 h / 0 - 5 °C

1.2: 1 h / 75 °C

2.1: pyridine; copper diacetate / dichloromethane / 16 h / 23 °C

3.1: hydrogenchloride; hydrogen; palladium 10% on activated carbon / methanol / 6 h / 23 °C

4.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide; tetrahydrofuran / 3 h / 23 °C

4.2: 36 h

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 5 h / 23 °C

With pyridine; hydrogenchloride; palladium 10% on activated carbon; tetrabutyl ammonium fluoride; hydrogen; copper diacetate; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; sodium nitrite; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 59997-51-2
trimethylacetylacetonitrile

: 1402581-37-6
N-[[5-tert-butyl-2-(3-chlorophenyl)-2H-pyrazol-3-yl]methyl]-2-[3-fluoro-4-(1-hydroxycyclopropyl)phenyl]propionamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrazine hydrate / ethanol / 3 h / Reflux

2.1: hydrogenchloride; sodium nitrite / water / 1 h / 0 - 5 °C

2.2: 1 h / 75 °C

3.1: pyridine; copper diacetate / dichloromethane / 16 h / 23 °C

4.1: hydrogenchloride; hydrogen; palladium 10% on activated carbon / methanol / 6 h / 23 °C

5.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide; tetrahydrofuran / 3 h / 23 °C

5.2: 36 h

6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 5 h / 23 °C

With pyridine; hydrogenchloride; palladium 10% on activated carbon; tetrabutyl ammonium fluoride; hydrogen; copper diacetate; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; sodium nitrite; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;