N-((3-tert-butyl-1-(3-chlorophenyl)-1H-pyrazol-5-yl)methyl)-2-(4-(1-(tert-butyldimethylsilyloxy)cyclopropyl)-3-fluorophenyl)propanamide

Base Information

Chemical Name:N-((3-tert-butyl-1-(3-chlorophenyl)-1H-pyrazol-5-yl)methyl)-2-(4-(1-(tert-butyldimethylsilyloxy)cyclopropyl)-3-fluorophenyl)propanamide
CAS No.:1402585-45-8
Molecular Formula:C₃₂H₄₃ClFN₃O₂Si
Molecular Weight:584.249
Hs Code.:

Synonyms:N-((3-tert-butyl-1-(3-chlorophenyl)-1H-pyrazol-5-yl)methyl)-2-(4-(1-(tert-butyldimethylsilyloxy)cyclopropyl)-3-fluorophenyl)propanamide

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Chemical Property of N-((3-tert-butyl-1-(3-chlorophenyl)-1H-pyrazol-5-yl)methyl)-2-(4-(1-(tert-butyldimethylsilyloxy)cyclopropyl)-3-fluorophenyl)propanamide

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Technology Process of N-((3-tert-butyl-1-(3-chlorophenyl)-1H-pyrazol-5-yl)methyl)-2-(4-(1-(tert-butyldimethylsilyloxy)cyclopropyl)-3-fluorophenyl)propanamide

There total 18 articles about N-((3-tert-butyl-1-(3-chlorophenyl)-1H-pyrazol-5-yl)methyl)-2-(4-(1-(tert-butyldimethylsilyloxy)cyclopropyl)-3-fluorophenyl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 1254713-63-7
(3-tert-butyl-1-(3-chlorophenyl)-1H-pyrazol-5-yl)methanamine

: 1402585-49-2
2-(4-(1-(tert-butyldimethylsilyloxy)cyclopropyl)-3-fluorophenyl)propanoic acid

: 1402585-45-8
N-((3-tert-butyl-1-(3-chlorophenyl)-1H-pyrazol-5-yl)methyl)-2-(4-(1-(tert-butyldimethylsilyloxy)cyclopropyl)-3-fluorophenyl)propanamide

Guidance literature:: 2-(4-(1-(tert-butyldimethylsilyloxy)cyclopropyl)-3-fluorophenyl)propanoic acid; With benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide; at 23 ℃; for 3h;

(3-tert-butyl-1-(3-chlorophenyl)-1H-pyrazol-5-yl)methanamine; In tetrahydrofuran; N,N-dimethyl-formamide; for 36h;

Reference yield:

: 82560-12-1,1237537-54-0
3-tert-butyl-1H-pyrazole-5-amine

: 1402585-45-8
N-((3-tert-butyl-1-(3-chlorophenyl)-1H-pyrazol-5-yl)methyl)-2-(4-(1-(tert-butyldimethylsilyloxy)cyclopropyl)-3-fluorophenyl)propanamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride; sodium nitrite / water / 1 h / 0 - 5 °C

1.2: 1 h / 75 °C

2.1: pyridine; copper diacetate / dichloromethane / 16 h / 23 °C

3.1: hydrogenchloride; hydrogen; palladium 10% on activated carbon / methanol / 6 h / 23 °C

4.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide; tetrahydrofuran / 3 h / 23 °C

4.2: 36 h

With pyridine; hydrogenchloride; palladium 10% on activated carbon; hydrogen; copper diacetate; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; sodium nitrite; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 598-98-1
Methyl pivalate

: 1402585-45-8
N-((3-tert-butyl-1-(3-chlorophenyl)-1H-pyrazol-5-yl)methyl)-2-(4-(1-(tert-butyldimethylsilyloxy)cyclopropyl)-3-fluorophenyl)propanamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / paraffin oil; 1,4-dioxane / 0.75 h

1.2: 3.25 h / Reflux

2.1: hydrazine hydrate / ethanol / 3 h / Reflux

3.1: hydrogenchloride; sodium nitrite / water / 1 h / 0 - 5 °C

3.2: 1 h / 75 °C

4.1: sodium hydride / N,N-dimethyl-formamide / 0.25 h / 23 °C

4.2: 0.5 h / 100 °C

5.1: hydrogenchloride; hydrogen; palladium 10% on activated carbon / methanol / 6 h / 23 °C

6.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide; tetrahydrofuran / 3 h / 23 °C

6.2: 36 h

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; sodium hydride; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; sodium nitrite; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water; N,N-dimethyl-formamide; paraffin oil;